UniProt Accession

 RPE_HUMAN; Q96AT9; A8K4S0; O43767; Q53TV9; Q8N215; Q96N34; Q9BSB5 

Genbank Protein ID

 AK056028; AK093658; AK291035; AC007038; CH471063; CH471063; BC005148; BC016764; BC072401; AJ224326 

Genbank Nucleotide ID

 BAB71076.1; BAC04212.1; BAF83724.1; AAX93087.1; EAW70473.1; EAW70474.1; AAH05148.2; AAH16764.1; AAH72401.1; CAA11895.1 

Protein Name

 Ribulose-phosphate 3-epimerase 

Protein Synonyms/Alias

 Ribulose-5-phosphate-3-epimerase 

Gene Name

 RPE 

Gene Synonyms/Alias

 HUSSY-17 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
223	VCSEAAQKRSLDR**	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate. 

Sequence Annotation

 REGION 146 149 Substrate binding.
 REGION 197 198 Substrate binding.
 ACT_SITE 37 37 Proton acceptor (Probable).
 ACT_SITE 175 175 Proton donor (Probable).
 METAL 35 35 Divalent metal cation.
 METAL 37 37 Divalent metal cation.
 METAL 70 70 Divalent metal cation.
 METAL 175 175 Divalent metal cation.
 BINDING 10 10 Substrate.
 BINDING 70 70 Substrate.
 BINDING 177 177 Substrate; via amide nitrogen.  

Keyword

 3D-structure; Alternative splicing; Carbohydrate metabolism; Cobalt; Complete proteome; Iron; Isomerase; Manganese; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 228 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0046872; F:metal ion binding; IDA:UniProtKB.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0004750; F:ribulose-phosphate 3-epimerase activity; IDA:UniProtKB.
 GO:0006098; P:pentose-phosphate shunt; IDA:UniProtKB.
 GO:0009052; P:pentose-phosphate shunt, non-oxidative branch; IEA:Compara. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR026019; Ribul_P_3_epim.
 IPR000056; Ribul_P_3_epim-like.
 IPR011060; RibuloseP-bd_barrel. 

Pfam

 PF00834; Ribul_P_3_epim 

SMART

  

PROSITE

 PS01085; RIBUL_P_3_EPIMER_1
 PS01086; RIBUL_P_3_EPIMER_2 

PRINTS