| Tag | Content |
|---|
| CPLM ID | CPLM-006109 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 4-hydroxybenzoate polyprenyltransferase, mitochondrial |
Protein Synonyms/Alias | Para-hydroxybenzoate--polyprenyltransferase; PHB:polyprenyltransferase |
Gene Name | COQ2 |
Gene Synonyms/Alias | YNR041C; N3419 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | SSSSPSSKESAPVFT | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB (By similarity). |
Sequence Annotation | REGION 134 156 Allylic polyprenyl diphosphate-binding |
Keyword | Complete proteome; Isoprene biosynthesis; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transferase; Transit peptide; Transmembrane; Transmembrane helix; Ubiquinone biosynthesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 372 AA |
Protein Sequence | MFIWQRKSIL LGRSILGSGR VTVAGIIGSS RKRYTSSSSS SSSPSSKESA PVFTSKELEV 60
ARKERLDGLG PFVSRLPKKW IPYAELMRLE KPVGTWLLYL PCSWSILMGA MMQGATLSAT 120
AGMLGIFGVG ALVMRGAGCT INDFLDRKLD QRVIRSVERP IASGRVSPRR ALVFLGAQTL 180
VGMGVLSLLP AQCWWLGLAS LPIVFTYPLF KRFTYYPQAA LSACFNWGAL LGFPAMGVMS 240
WPTMIPLYLS SYLWCMTYDT IYAHQDKKFD IKAGIKSTAL AWGPRTKSIM KAMSASQIAL 300
LAVAGLNSGL LWGPGFIGGL GVFAYRLFSM IKKVDLDNPK NCWKYFNANI NTGLYFTYAL 360
AVDYILRLFG FL 372 |
Gene Ontology | GO:0032592; C:integral to mitochondrial membrane; IDA:SGD. GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome. GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IEA:EC. GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:EC. GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; IMP:SGD. GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. GO:0006744; P:ubiquinone biosynthetic process; IMP:SGD. |
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