UniProt Accession

 E9Q4T8_MOUSE; E9Q4T8 

Genbank Protein ID

 AC161416; AC166157 

Genbank Nucleotide ID

  

Protein Name

 Cullin-3 

Protein Synonyms/Alias

  

Gene Name

 Cul3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
169	NSASVYIKKVEARIN	acetylation	[1]
169	NSASVYIKKVEARIN	ubiquitination	[2]
196	STEEPIVKVVERELI	ubiquitination	[2]
226	VHMLKNGKTEDLACM	ubiquitination	[2]
235	EDLACMYKLFSRVPN	acetylation	[3]
283	IQGLLDLKSRFDRFL	ubiquitination	[2]
585	LTKEPKSKEIESGHI	acetylation	[4]
602	VNDQFTSKLHRVKIQ	ubiquitination	[2]
676	LPSPVVIKKRIEGLI	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 702 AA 

Protein Sequence

Gene Ontology

 GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0008054; P:cyclin catabolic process; ISS:MGI.
 GO:0007369; P:gastrulation; IMP:MGI.
 GO:0001831; P:trophectodermal cellular morphogenesis; IMP:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IDA:MGI. 

Interpro

 IPR016157; Cullin_CS.
 IPR016158; Cullin_homology.
 IPR001373; Cullin_N.
 IPR019559; Cullin_neddylation_domain.
 IPR016159; Cullin_repeat-like_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00888; Cullin
 PF10557; Cullin_Nedd8 

SMART

 SM00182; CULLIN
 SM00884; Cullin_Nedd8 

PROSITE

 PS01256; CULLIN_1
 PS50069; CULLIN_2 

PRINTS