UniProt Accession

 J3KN32_HUMAN; J3KN32 

Genbank Protein ID

 AL132801; AL136293; CH471061 

Genbank Nucleotide ID

 EAW81793.1 

Protein Name

 REST corepressor 1 

Protein Synonyms/Alias

 REST corepressor 1, isoform CRA_a 

Gene Name

 RCOR1 

Gene Synonyms/Alias

 hCG_24743 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	VPDFDPAKLARRSQE	ubiquitination	[1, 2]
421	NKSVVQVKNFFVNYR	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 485 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Compara. 

Interpro

 IPR000949; ELM2_dom.
 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom. 

Pfam

 PF01448; ELM2
 PF00249; Myb_DNA-binding 

SMART

 SM00717; SANT 

PROSITE

 PS51156; ELM2
 PS51293; SANT 

PRINTS