CPLM-012315

Genbank Nucleotide ID

Protein Synonyms/Alias

Cell cycle-associated protein 1; Cytoplasmic activation- and proliferation-associated protein 1; GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; p137GPI; Membrane component chromosome 11 surface marker 1; RNA granule protein 105

GPIAP1; GPIP137; M11S1; RNG105

Homo sapiens (Human)

Position	Peptide	Type	References
55	AVQTEAMKQILGVID	ubiquitination	[1]
64	ILGVIDKKLRNLEKK	ubiquitination	[1]
74	NLEKKKGKLDDYQER	acetylation	[2]
74	NLEKKKGKLDDYQER	ubiquitination	[1, 3, 4, 5]
98	DQLDAVSKYQEVTNN	ubiquitination	[1]
110	TNNLEFAKELQRSFM	ubiquitination	[1, 3, 4, 5]
125	ALSQDIQKTIKKTAR	ubiquitination	[1, 3, 4, 5, 6, 7]
129	DIQKTIKKTARREQL	ubiquitination	[1]
158	ELQYVLDKLGDDEVR	ubiquitination	[6]
223	DLLEGKEKPVCGTTY	ubiquitination	[1]
234	GTTYKVLKEIVERVF	ubiquitination	[1]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
[3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]

Functional Description

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (By similarity).

REGION 360 381 G3BP1-binding.
MOD_RES 2 2 N-acetylproline.
MOD_RES 10 10 Phosphoserine.

Acetylation; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Glycoprotein; Phosphoprotein; Polymorphism; Protein synthesis inhibitor; Reference proteome; RNA-binding.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.
GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
GO:0050775; P:positive regulation of dendrite morphogenesis; ISS:UniProtKB.
GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB.

IPR022070; Caprin-1_C.