CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008008
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carbonic anhydrase 4 
Protein Synonyms/Alias
 Carbonate dehydratase IV; Carbonic anhydrase IV; CA-IV 
Gene Name
 Ca4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
77TFVGYDQKKKWEVKNacetylation[1]
143MEMHVVHKKMTTGDKacetylation[1]
243EEPIKIHKDQFLEFSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity). 
Sequence Annotation
 REGION 222 223 Substrate binding (By similarity).
 ACT_SITE 87 87 Proton acceptor (By similarity).
 METAL 114 114 Zinc; catalytic (By similarity).
 METAL 116 116 Zinc; catalytic (By similarity).
 METAL 139 139 Zinc; catalytic (By similarity).
 LIPID 281 281 GPI-anchor amidated serine (By
 CARBOHYD 193 193 N-linked (GlcNAc...) (Potential).
 DISULFID 23 35 By similarity.
 DISULFID 45 226 By similarity.  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; Lyase; Membrane; Metal-binding; Reference proteome; Signal; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 309 AA 
Protein Sequence
MQLLLALLAL AYVAPSTEDS HWCYEIQAKE PNSHCSGPEQ WTGDCKKNQQ SPINIVTSKT 60
KLNPSLTPFT FVGYDQKKKW EVKNNQHSVE MSLGEDIYIF GGDLPTQYKA IQLHLHWSEE 120
SNKGSEHSID GKHFAMEMHV VHKKMTTGDK VQDSDSKDKI AVLAFMVEVG NEVNEGFQPL 180
VEALSRLSKP FTNSTVSESC LQDMLPEKKK LSAYFRYQGS LTTPGCDETV IWTVFEEPIK 240
IHKDQFLEFS KKLYYDQEQK LNMKDNVRPL QPLGNRQVFR SHASGRLLSL PLPTLLVPTL 300
TCLVASFLH 309 
Gene Ontology
 GO:0031362; C:anchored to external side of plasma membrane; IEA:Compara.
 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0042383; C:sarcolemma; IDA:RGD.
 GO:0016529; C:sarcoplasmic reticulum; IDA:RGD.
 GO:0030667; C:secretory granule membrane; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0030658; C:transport vesicle membrane; IEA:Compara.
 GO:0004089; F:carbonate dehydratase activity; IDA:RGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0015701; P:bicarbonate transport; IEA:Compara.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
 GO:0048513; P:organ development; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0048545; P:response to steroid hormone stimulus; IEP:RGD. 
Interpro
 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018343; Carbonic_anhydrase_CA4. 
Pfam
 PF00194; Carb_anhydrase 
SMART
 SM01057; Carb_anhydrase 
PROSITE
 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 
PRINTS