UniProt Accession

 UBCP1_MOUSE; Q8BGR9; A2ACX3; Q52L62; Q5XJH1; Q6PH96; Q99LT3 

Genbank Protein ID

 AK043952; AK050031; AK147744; AL669944; BC002236; BC056652; BC083331; BC085111; BC106093 

Genbank Nucleotide ID

 BAC31711.1; BAC34039.1; BAE28110.1; CAM22830.1; AAH02236.1; AAH56652.1; AAH83331.1; AAH85111.1; AAI06094.1 

Protein Name

 Ubiquitin-like domain-containing CTD phosphatase 1 

Protein Synonyms/Alias

 Nuclear proteasome inhibitor UBLCP1 

Gene Name

 Ublcp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
71	LKLKPNTKIMMMGTR	acetylation	[1]
195	KWIEAKMKELGVSTN	ubiquitination	[2]
267	MNPQNGLKIRPFMKA	ubiquitination	[2]
292	VKLTQYLKEIAKLDD	ubiquitination	[2]
306	DFLELNHKYWERYLS	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity). 

Sequence Annotation

 DOMAIN 3 81 Ubiquitin-like.
 DOMAIN 133 294 FCP1 homology.
 REGION 133 294 Phosphatase (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 117 117 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Hydrolase; Nucleus; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW. 

Interpro

 IPR023214; HAD-like_dom.
 IPR011943; HAD-SF_hydro_IIID.
 IPR004274; NIF.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF03031; NIF
 PF00240; ubiquitin 

SMART

 SM00577; CPDc
 SM00213; UBQ 

PROSITE

 PS50969; FCP1
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 

PRINTS