| Tag | Content |
|---|
| CPLM ID | CPLM-022210 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Trimethyllysine dioxygenase, mitochondrial |
Protein Synonyms/Alias | Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; Epsilon-trimethyllysine hydroxylase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TML dioxygenase; TMLD |
Gene Name | TMLHE |
Gene Synonyms/Alias | TMLH |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 29 | SRLQDLLKGGVIYPA | ubiquitination | [1] | | 146 | YDLNWLVKNSYEGQK | ubiquitination | [1] | | 247 | RGDTAYTKLALDRHT | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). |
Sequence Annotation | METAL 242 242 Iron; catalytic (By similarity).
METAL 244 244 Iron; catalytic (By similarity).
METAL 389 389 Iron; catalytic (By similarity).
MOD_RES 236 236 N6-acetyllysine. |
Keyword | Acetylation; Alternative promoter usage; Alternative splicing; Carnitine biosynthesis; Complete proteome; Dioxygenase; Iron; Metal-binding; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 421 AA |
Protein Sequence | MKIDSFLPIL RMWYHRLSHL HSRLQDLLKG GVIYPALPQP NFKSLLPLAV HWHHTASKSL 60
TCAWQQHEDH FELKYANTVM RFDYVWLRDH CRSASCYNSK THQRSLDTAS VDLCIKPKTI 120
RLDETTLFFT WPDGHVTKYD LNWLVKNSYE GQKQKVIQPR ILWNAEIYQQ AQVPSVDCQS 180
FLETNEGLKK FLQNFLLYGI AFVENVPPTQ EHTEKLAERI SLIRETIYGR MWYFTSDFSR 240
GDTAYTKLAL DRHTDTTYFQ EPCGIQVFHC LKHEGTGGRT LLVDGFYAAE QVLQKAPEEF 300
ELLSKVPLKH EYIEDVGECH NHMIGIGPVL NIYPWNKELY LIRYNNYDRA VINTVPYDVV 360
HRWYTAHRTL TIELRRPENE FWVKLKPGRV LFIDNWRVLH GRECFTGYRQ LCGCYLTRDD 420
VLNTARLLGL QA 432 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; TAS:Reactome. GO:0005739; C:mitochondrion; IDA:BHF-UCL. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0031418; F:L-ascorbic acid binding; IEA:InterPro. GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. GO:0050353; F:trimethyllysine dioxygenase activity; IDA:BHF-UCL. GO:0045329; P:carnitine biosynthetic process; IDA:BHF-UCL. GO:0051354; P:negative regulation of oxidoreductase activity; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |