UniProt Accession

 KCD16_HUMAN; Q68DU8; Q9P2M9 

Genbank Protein ID

 AB037738; CR749266; BC111962; BC113435 

Genbank Nucleotide ID

 BAA92555.1; CAH18122.1; AAI11963.1; AAI13436.1 

Protein Name

 BTB/POZ domain-containing protein KCTD16 

Protein Synonyms/Alias

 Potassium channel tetramerization domain-containing protein 16 

Gene Name

 KCTD16 

Gene Synonyms/Alias

 KIAA1317 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
185	REGQADAKFRRVPRI	ubiquitination	[1, 2, 3]
231	SRFYLKFKHLERAFD	ubiquitination	[4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). 

Sequence Annotation

 DOMAIN 25 98 BTB.
 MOD_RES 112 112 Phosphotyrosine (By similarity).
 MOD_RES 130 130 Phosphoserine (By similarity).
 MOD_RES 390 390 Phosphoserine (By similarity).  

Keyword

 Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 428 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0043235; C:receptor complex; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:Compara. 

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR003131; T1-type_BTB. 

Pfam

 PF02214; K_tetra 

SMART

 SM00225; BTB 

PROSITE

 PS50097; BTB 

PRINTS