CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022201
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pantothenate kinase 4 
Protein Synonyms/Alias
 hPanK4; Pantothenic acid kinase 4 
Gene Name
 PANK4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118HLVNTETKVIQATGGubiquitination[1]
129ATGGGAYKFKDLIEEubiquitination[1]
131GGGAYKFKDLIEEKLubiquitination[2]
137FKDLIEEKLRLKVDKubiquitination[1, 3]
141IEEKLRLKVDKEDVMubiquitination[2]
171HEAFVYQKDSDPEFRubiquitination[1, 2]
234ALLTKTKKFDELLHLubiquitination[2, 3]
278LIASSFGKSATADQEubiquitination[1]
288TADQEFSKEDMAKSLubiquitination[1, 2]
487FRQKYWNKLQTLRQQubiquitination[2, 3]
590YFGFEEAKRKLQERPubiquitination[1, 2]
707LDLSRLDKGLAALVRubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity). 
Sequence Annotation
 BINDING 196 196 Acetyl-CoA (By similarity).
 BINDING 199 199 Acetyl-CoA (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 320 320 Nitrated tyrosine (By similarity).  
Keyword
 Acetylation; ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm; Kinase; Nitration; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 773 AA 
Protein Sequence
MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY YSTVQHKVAK 60
VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY IEACLDFIKD HLVNTETKVI 120
QATGGGAYKF KDLIEEKLRL KVDKEDVMTC LIKGCNFVLK NIPHEAFVYQ KDSDPEFRFQ 180
TNHPHIFPYL LVNIGSGVSI VKVETEDRFE WVGGSSIGGG TFWGLGALLT KTKKFDELLH 240
LASRGQHSNV DMLVRDVYGG AHQTLGLSGN LIASSFGKSA TADQEFSKED MAKSLLHMIS 300
NDIGQLACLH ARLHSLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA LFLRHEGYLG 360
AIGAFLKGAE QDNPNQYSWG ENYAGSSGLM SASPELGPAQ RARSGTFDLL EMDRLERPLV 420
DLPLLLDPPS YVPDTVDLTD DALARKYWLT CFEEALDGVV KRAVASQPDS VDAAERAEKF 480
RQKYWNKLQT LRQQPFAYGT LTVRSLLDTR EHCLNEFNFP DPYSKVKQRE NGVALRCFPG 540
VVRSLDALGW EERQLALVKG LLAGNVFDWG AKAVSAVLES DPYFGFEEAK RKLQERPWLV 600
DSYSEWLQRL KGPPHKCALI FADNSGIDII LGVFPFVREL LLRGTEVILA CNSGPALNDV 660
THSESLIVAE RIAGMDPVVH SALQEERLLL VQTGSSSPCL DLSRLDKGLA ALVRERGADL 720
VVIEGMGRAV HTNYHAALRC ESLKLAVIKN AWLAERLGGR LFSVIFKYEV PAE 773 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004594; F:pantothenate kinase activity; IEA:EC.
 GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR002791; DUF89.
 IPR015844; PanK_long.
 IPR004567; Type_II_PanK. 
Pfam
 PF01937; DUF89
 PF03630; Fumble 
SMART
  
PROSITE
  
PRINTS