UniProt Accession

 LGUL_RAT; Q6P7Q4 

Genbank Protein ID

 BC061570 

Genbank Nucleotide ID

 AAH61570.1 

Protein Name

 Lactoylglutathione lyase 

Protein Synonyms/Alias

 Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase 

Gene Name

 Glo1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
148	RFEELGVKFVKKPDD	acetylation	[1]
151	ELGVKFVKKPDDGKM	acetylation	[1]
157	VKKPDDGKMKGLAFV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B (By similarity). 

Sequence Annotation

 METAL 34 34 Zinc (By similarity).
 METAL 100 100 Zinc (By similarity).
 METAL 127 127 Zinc (By similarity).
 METAL 173 173 Zinc (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 107 107 Phosphothreonine (By similarity).
 MOD_RES 139 139 S-glutathionyl cysteine (By similarity).
 MOD_RES 148 148 N6-acetyllysine (By similarity).
 DISULFID 19 20 By similarity.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Disulfide bond; Glutathionylation; Lyase; Metal-binding; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0004462; F:lactoylglutathione lyase activity; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005975; P:carbohydrate metabolic process; IDA:RGD.
 GO:0006749; P:glutathione metabolic process; IDA:RGD.
 GO:0009438; P:methylglyoxal metabolic process; IDA:RGD.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR004360; Glyas_Fos-R_dOase_dom.
 IPR004361; Glyoxalase_1.
 IPR018146; Glyoxalase_1_CS. 

Pfam

 PF00903; Glyoxalase 

SMART

  

PROSITE

 PS00934; GLYOXALASE_I_1
 PS00935; GLYOXALASE_I_2 

PRINTS