UniProt Accession

 Q05BE7_MOUSE; Q05BE7 

Genbank Protein ID

 AC132954; AC133183; BC050108 

Genbank Nucleotide ID

 AAH50108.1 

Protein Name

 Numb protein 

Protein Synonyms/Alias

 Protein numb homolog 

Gene Name

 Numb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
174	ERKQKREKECGVTAT	ubiquitination	[1]
211	AEREEIMKQLQDAKK	ubiquitination	[1]
286	GFPALSQKMSPFKRQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 322 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0034332; P:adherens junction organization; IGI:MGI.
 GO:0007409; P:axonogenesis; IDA:MGI.
 GO:0030900; P:forebrain development; IMP:MGI.
 GO:0060487; P:lung epithelial cell differentiation; IMP:MGI.
 GO:0045746; P:negative regulation of Notch signaling pathway; IMP:MGI.
 GO:0007405; P:neuroblast proliferation; IGI:MGI.
 GO:0030862; P:positive regulation of polarized epithelial cell differentiation; IMP:MGI. 

Interpro

 IPR010449; Numb_domain.
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom. 

Pfam

 PF06311; NumbF
 PF00640; PID 

SMART

 SM00462; PTB 

PROSITE

 PS01179; PID 

PRINTS