UniProt Accession

 PEN2_HUMAN; Q9NZ42; B2R5L9 

Genbank Protein ID

 AF220053; AK312233; BC009575 

Genbank Nucleotide ID

 AAF67646.1; BAG35166.1; AAH09575.1 

Protein Name

 Gamma-secretase subunit PEN-2 

Protein Synonyms/Alias

 Presenilin enhancer protein 2 

Gene Name

 PSENEN 

Gene Synonyms/Alias

 PEN2; MDS033 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	ERVSNEEKLNLCRKY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane; Notch signaling pathway; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 101 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:HGNC.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:HGNC.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IDA:HGNC.
 GO:0042987; P:amyloid precursor protein catabolic process; TAS:HGNC.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0006509; P:membrane protein ectodomain proteolysis; IDA:HGNC.
 GO:0031293; P:membrane protein intracellular domain proteolysis; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0007220; P:Notch receptor processing; TAS:HGNC.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0043085; P:positive regulation of catalytic activity; IDA:HGNC.
 GO:0016485; P:protein processing; IDA:HGNC. 

Interpro

 IPR019379; Gamma_Secretase_Asp_P_PEN2. 

Pfam

 PF10251; PEN-2 

SMART

  

PROSITE

  

PRINTS