CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038271
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nucleoside diphosphate kinase 
Protein Synonyms/Alias
  
Gene Name
 Gm20390 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12ERTFIAIKPDGVQRGacetylation[1, 2, 3]
12ERTFIAIKPDGVQRGsuccinylation[3]
12ERTFIAIKPDGVQRGubiquitination[4]
26GLVGEIIKRFEQKGFacetylation[1, 3]
26GLVGEIIKRFEQKGFsuccinylation[3]
26GLVGEIIKRFEQKGFubiquitination[4]
31IIKRFEQKGFRLVGLacetylation[1]
39GFRLVGLKFLQASEDacetylation[1]
39GFRLVGLKFLQASEDubiquitination[4]
49QASEDLLKEHYTDLKacetylation[1, 2]
49QASEDLLKEHYTDLKubiquitination[4]
56KEHYTDLKDRPFFTGacetylation[1]
56KEHYTDLKDRPFFTGubiquitination[4]
85WEGLNVVKTGRVMLGacetylation[1]
100ETNPADSKPGTIRGDacetylation[1, 2, 3, 5]
100ETNPADSKPGTIRGDsuccinylation[3]
100ETNPADSKPGTIRGDubiquitination[4]
154GFRLVAMKFLRASEEacetylation[1]
154GFRLVAMKFLRASEEubiquitination[4]
164RASEEHLKQHYIDLKacetylation[1, 2, 5]
164RASEEHLKQHYIDLKubiquitination[4]
171KQHYIDLKDRPFFPGacetylation[2, 6]
171KQHYIDLKDRPFFPGubiquitination[4]
200WEGLNVVKTGRVMLGacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [6] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 267 AA 
Protein Sequence
MANSERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF LQASEDLLKE HYTDLKDRPF 60
FTGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRTMANLE 120
RTFIAIKPDG VQRGLVGEII KRFEQKGFRL VAMKFLRASE EHLKQHYIDL KDRPFFPGLV 180
KYMNSGPVVA MVWEGLNVVK TGRVMLGETN PADSKPGTIR GDFCIQVGRN IIHGSDSVES 240
AEKEIHLWFK PEELIDYKSC AHDWVYE 267 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IEA:EC.
 GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
 GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
 GO:0006228; P:UTP biosynthetic process; IEA:InterPro. 
Interpro
 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 
Pfam
 PF00334; NDK 
SMART
 SM00562; NDK 
PROSITE
 PS00469; NDP_KINASES 
PRINTS
 PR01243; NUCDPKINASE.