UniProt Accession

 TSN3_HUMAN; O60637; A6NEH4; B3KQQ2; B4DP19; Q9BW22; Q9NVX9 

Genbank Protein ID

 AF054840; AF133423; AK001326; AK001305; AK001310; AK075336; AK075482; AK298157; AC090181; CH471136; CH471136; CH471136; BC000704; BC004280; BC009248; BC011206 

Genbank Nucleotide ID

 AAC69716.1; AAF08362.1; BAA91627.1; BAA91613.1; BAA91615.1; BAG52114.1; BAG52152.1; BAG60431.1; EAW99209.1; EAW99210.1; EAW99211.1; AAH00704.1; AAH04280.1; AAH09248.1; AAH11206.1 

Protein Name

 Tetraspanin-3 

Protein Synonyms/Alias

 Tspan-3; Tetraspanin TM4-A; Transmembrane 4 superfamily member 8 

Gene Name

 TSPAN3 

Gene Synonyms/Alias

 TM4SF8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
110	LGYVYRAKVENEVDR	ubiquitination	[1]
121	EVDRSIQKVYKTYNG	ubiquitination	[1, 2]
124	RSIQKVYKTYNGTNP	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair (By similarity). 

Sequence Annotation

 CARBOHYD 127 127 N-linked (GlcNAc...) (Potential).
 CARBOHYD 152 152 N-linked (GlcNAc...) (Potential).
 CARBOHYD 167 167 N-linked (GlcNAc...) (Potential).
 CARBOHYD 183 183 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 253 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; TAS:ProtInc. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.