| Tag | Content |
|---|
| CPLM ID | CPLM-014973 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | G-protein-signaling modulator 1 |
Protein Synonyms/Alias | Activator of G-protein signaling 3 |
Gene Name | Gpsm1 |
Gene Synonyms/Alias | Ags3; C10a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 117 | GNLGNTLKVLGRFDE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. |
Sequence Annotation | REPEAT 28 61 TPR 1.
REPEAT 66 99 TPR 2.
REPEAT 106 139 TPR 3.
REPEAT 146 178 TPR 4.
REPEAT 180 199 TPR 5.
REPEAT 206 239 TPR 6.
REPEAT 246 279 TPR 7.
REPEAT 286 319 TPR 8.
REPEAT 326 359 TPR 9.
DOMAIN 493 515 GoLoco 1.
DOMAIN 546 568 GoLoco 2.
DOMAIN 594 616 GoLoco 3.
DOMAIN 628 650 GoLoco 4.
REGION 1 507 Mediates association with membranes (By
REGION 361 485 Interaction with STK11/LKB1 (By
MOD_RES 410 410 Phosphoserine (By similarity).
MOD_RES 469 469 Phosphoserine (By similarity).
MOD_RES 490 490 Phosphoserine (By similarity).
MOD_RES 491 491 Phosphoserine (By similarity).
MOD_RES 653 653 Phosphoserine. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Membrane; Neurogenesis; Phosphoprotein; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 673 AA |
Protein Sequence | MASPAPPVAE ELPGPASRRL YSRMEASCLE LALEGERLCK AGDFKAGVAF FEAAVQVGTE 60
DLKTLSAIYS QLGNAYFYLK EYARALQFHK HDLLLARTIG DRMGEAKASG NLGNTLKVLG 120
RFDEAIVCCQ RHLDIAQEQG DKVGEARALY NIGNVYHAKG KQLSWNAAQD PGHLPPDVRE 180
TLHRASEFYE RNLSLVKELG DRAAQGRAYG NLGNTHYLLG NFTEATTFHK ERLAIAKEFG 240
DKAAERRAYS NLGNAHIFLG RFDVAAEHYK KTLQLSRQLR DQAVEAQACY SLGNTYTLLQ 300
DYERAAEYHL RHLVIAQELA DRVGEGRACW SLGNAYVSMG SPAQALTFAK KHLQISQEIG 360
DRNGELTARM NIAHLQLALG RLTSPAAAEK PDLAGYEAQG ARPKRTQRLS AETWDLLRLP 420
LDREQNGETH HTGDWRGPGR DSLPLPMRSR KYQEGPDAIE RRPREGSHSP LDSADVRVQV 480
PRTGIPRAPS SDEECFFDLL SKFQSSRMDD QRCPLEEGQA GAAEATAAPS VEDRAAQSSV 540
TASPQTEEFF DLIASSQSRR LDDQRASVGS LPGLRITLNN VGHLRGDGDA QEPGDEFFNM 600
LIKYQSSRID DQRCPPPDVL PRGPTMPDED FFSLIQRVQA KRMDEQRVDL AGSPEQEASG 660
LPDPQQQCPP GAS 673 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005092; F:GDP-dissociation inhibitor activity; IEA:InterPro. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007399; P:nervous system development; IEA:UniProtKB-KW. GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |