UniProt Accession

 RFOX2_HUMAN; O43251; A4F5G8; A8K5Z5; B0QYY8; B0QYY9; Q0PRL5; Q0VH35; Q5TF71; Q6IC09; Q8TD00; Q8WYB1; Q96DZ6; Q96NL7; Q9UGW4; Q9UH33 

Genbank Protein ID

 AY072786; AF229058; AY960684; AL009266; CR456559; AK055213; AK291460; DQ778625; AL079295; AL049748; AL079295; AL049748; AL079295; AL049748; BC013115; BC025281; AM419009 

Genbank Nucleotide ID

 AAL67150.1; AAL71905.1; AAX84843.1; CAA15842.1; CAG30445.1; BAB70875.1; BAF84149.1; ABG77459.1; CAI19059.1; CAI19059.1; CAQ07599.1; CAQ07599.1; CAQ07600.1; CAQ07600.1; AAH13115.1; AAH25281.1; CAL91352.1 

Protein Name

 RNA binding protein fox-1 homolog 2 

Protein Synonyms/Alias

 Fox-1 homolog B; Hexaribonucleotide-binding protein 2; RNA-binding motif protein 9; RNA-binding protein 9; Repressor of tamoxifen transcriptional activity 

Gene Name

 RBFOX2 

Gene Synonyms/Alias

 FOX2; HRNBP2; RBM9; RTA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
160	IFNERGSKGFGFVTF	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. 

Sequence Annotation

 DOMAIN 121 197 RRM.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 390 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IDA:UniProtKB.
 GO:0030520; P:intracellular estrogen receptor signaling pathway; IDA:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:BHF-UCL.
 GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.
 GO:0010724; P:regulation of definitive erythrocyte differentiation; IEA:Compara.
 GO:0016070; P:RNA metabolic process; TAS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR025670; Fox-1_C_dom.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR017325; RNA-bd_Fox-1.
 IPR000504; RRM_dom. 

Pfam

 PF12414; Fox-1_C
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS