CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014258
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor erythroid 2-related factor 2 
Protein Synonyms/Alias
 NF-E2-related factor 2; NFE2-related factor 2; Nuclear factor, erythroid derived 2, like 2 
Gene Name
 Nfe2l2 
Gene Synonyms/Alias
 Nrf-2; Nrf2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
588GNVFLVPKSKKPDTKacetylation[1]
591FLVPKSKKPDTKKN*acetylation[1]
Reference
 [1] Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization.
 Kawai Y, Garduño L, Theodore M, Yang J, Arinze IJ.
 J Biol Chem. 2011 Mar 4;286(9):7629-40. [PMID: 21196497] 
Functional Description
 Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. 
Sequence Annotation
 DOMAIN 489 552 bZIP.
 REGION 491 510 Basic motif (By similarity).
 REGION 514 521 Leucine-zipper (By similarity).
 MOD_RES 40 40 Phosphoserine (By similarity).
 MOD_RES 207 207 Phosphoserine (By similarity).
 MOD_RES 588 588 N6-acetyllysine; by CREBBP (By
 MOD_RES 591 591 N6-acetyllysine; by CREBBP (By  
Keyword
 3D-structure; Acetylation; Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 597 AA 
Protein Sequence
MMDLELPPPG LQSQQDMDLI DILWRQDIDL GVSREVFDFS QRQKDYELEK QKKLEKERQE 60
QLQKEQEKAF FAQFQLDEET GEFLPIQPAQ HIQTDTSGSA SYSQVAHIPK QDALYFEDCM 120
QLLAETFPFV DDHESLALDI PSHAESSVFT APHQAQSLNS SLEAAMTDLS SIEQDMEQVW 180
QELFSIPELQ CLNTENKQLA DTTAVPSPEA TLTEMDSNYH FYSSISSLEK EVGNCGPHFL 240
HGFEDSFSSI LSTDDASQLT SLDSNPTLNT DFGDEFYSAF IAEPSDGGSM PSSAAISQSL 300
SELLDGTIEG CDLSLCKAFN PKHAEGTMEF NDSDSGISLN TSPSRASPEH SVESSIYGDP 360
PPGFSDSEME ELDSAPGSVK QNGPKAQPAH SPGDTVQPLS PAQGHSAPMR ESQCENTTKK 420
EVPVSPGHQK APFTKDKHSS RLEAHLTRDE LRAKALHIPF PVEKIINLPV DDFNEMMSKE 480
QFNEAQLALI RDIRRRGKNK VAAQNCRKRK LENIVELEQD LGHLKDEREK LLREKGENDR 540
NLHLLKRRLS TLYLEVFSML RDEDGKPYSP SEYSLQQTRD GNVFLVPKSK KPDTKKN 597 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0000785; C:chromatin; IDA:BHF-UCL.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071499; P:cellular response to laminar fluid shear stress; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IDA:BHF-UCL.
 GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030194; P:positive regulation of blood coagulation; IMP:BHF-UCL.
 GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0036003; P:positive regulation of transcription from RNA polymerase II promoter in response to stress; IEA:Compara.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; ISS:UniProtKB.
 GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
 GO:0045995; P:regulation of embryonic development; IGI:MGI.
 GO:2000121; P:regulation of removal of superoxide radicals; IMP:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR004827; bZIP.
 IPR008917; Euk_TF_DNA-bd. 
Pfam
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS