| Tag | Content |
|---|
| CPLM ID | CPLM-018815 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein neuro-d4 |
Protein Synonyms/Alias | BRG1-associated factor 45B; BAF45B; D4, zinc and double PHD fingers family 1 |
Gene Name | DPF1 |
Gene Synonyms/Alias | BAF45B; NEUD4 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 208 | YGIGGLRKRQDTASL | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
Sequence Annotation | ZN_FING 254 311 PHD-type 1.
ZN_FING 308 368 PHD-type 2. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 380 AA |
Protein Sequence | MGGLSARPTA GRTDPAGTCW GQDPGSKMAT VIPGPLSLGE DFYREAIEHC RSYNARLCAE 60
RSLRLPFLDS QTGVAQNNCY IWMEKTHRGP GLAPGQIYTY PARCWRKKRR LNILEDPRLR 120
PCEYKIDCEA PLKKEGGLPE GPVLEALLCA ETGEKKIELK EEETIMDCQK QQLLEFPHDL 180
EVEDLEDDIP RRKNRAKGKA YGIGGLRKRQ DTASLEDRDK PYVCDKFYKE LAWVPEAQRK 240
HTAKKAPDGT VIPNGYCDFC LGGSKKTGCP EDLISCADCG RSGHPSCLQF TVNMTAAVRT 300
YRWQCIECKS CSLCGTSEND GASWAGLTPQ DQLLFCDDCD RGYHMYCLSP PMAEPPEGSW 360
SCHLCLRHLK EKASAYITLT 380 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0071565; C:nBAF complex; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006917; P:induction of apoptosis; TAS:ProtInc. GO:0007399; P:nervous system development; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
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