CPLM-019497

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-019497

UniProt Accession

TOX2_HUMAN; Q96NM4; A8K1J1; E1P5X0; G3XAC7; Q5TE33; Q5TE34; Q5TE35; Q96IC9; Q9BQN5

Genbank Protein ID

AK055135; AK289906; AL121587; AL034419; AL121587; AL034419; AL121587; AL034419; AL034419; AL121587; AL034419; AL121587; AL034419; AL121587; AL035089; AL353797; CH471077; CH471077; CH471077; BC007636

Genbank Nucleotide ID

BAB70860.1; BAF82595.1; CAI21559.1; CAI21559.1; CAI21560.1; CAI21560.1; CAI21561.1; CAI21561.1; CAI42198.1; CAI42198.1; CAI42200.1; CAI42200.1; CAI42201.1; CAI42201.1; EAW75944.1; EAW75945.1; EAW75946.1

Protein Name

TOX high mobility group box family member 2

Protein Synonyms/Alias

Granulosa cell HMG box protein 1; GCX-1

Gene Name

TOX2

Gene Synonyms/Alias

C20orf100; GCX1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
274	RDTQAAIKGQNPSAT	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.

Sequence Annotation

DNA_BIND 255 323 HMG box.
REGION 76 114 Required for transcriptional activation
MOTIF 223 252 Nuclear localization signal (By

Keyword

Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

488 AA

Protein Sequence

MQQTRTEAVA GAFSRCLGFC GMRLGLLLLA RHWCIAGVFP QKFDGDSAYV GMSDGNPELL 60
STSQTYNGQS ENNEDYEIPP ITPPNLPEPS LLHLGDHEAS YHSLCHGLTP NGLLPAYSYQ 120
AMDLPAIMVS NMLAQDSHLL SGQLPTIQEM VHSEVAAYDS GRPGPLLGRP AMLASHMSAL 180
SQSQLISQMG IRSSIAHSSP SPPGSKSATP SPSSSTQEEE SEVHFKISGE KRPSADPGKK 240
AKNPKKKKKK DPNEPQKPVS AYALFFRDTQ AAIKGQNPSA TFGDVSKIVA SMWDSLGEEQ 300
KQSSPDQGET KSTQANPPAK MLPPKQPMYA MPGLASFLTP SDLQAFRSGA SPASLARTLG 360
SKSLLPGLSA SPPPPPSFPL SPTLHQQLSL PPHAQGALLS PPVSMSPAPQ PPVLPTPMAL 420
QVQLAMSPSP PGPQDFPHIS EFPSSSGSCS PGPSNPTSSG DWDSSYPSGE CGISTCSLLP 480
RDKSLYLT 488

Gene Ontology

GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.

Interpro

IPR009071; HMG_box_dom.

Pfam

PF00505; HMG_box

SMART

SM00398; HMG

PROSITE

PS50118; HMG_BOX_2

PRINTS