CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040786
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ran GTPase-activating protein 1 
Protein Synonyms/Alias
  
Gene Name
 RANGAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138CFTLQELKLNNCGMGubiquitination[1]
196NDNTFTEKGAVAMAEubiquitination[1, 2, 3]
206VAMAETLKTLRQVEVubiquitination[1]
224GDCLVRSKGAVAIADubiquitination[1]
241RGGLPKLKELNLSFCubiquitination[1, 4, 5]
251NLSFCEIKRDAALAVubiquitination[1]
397KLLRLGPKSSVLIAQubiquitination[1, 2, 3, 4, 5, 6, 7]
426LKVSSVFKDEATVRMubiquitination[1]
469LVHMGLLKSEDKVKAacetylation[5, 8, 9]
469LVHMGLLKSEDKVKAubiquitination[1, 2, 4, 7]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [8] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [9] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 532 AA 
Protein Sequence
MFVLGIPLCP ALSFSGGDDS QTQLFVSSKD VIKEIEDFDS LEALRLEGNT VGVEAARVIA 60
KALEKKSELK RCHWSDMFTG RLRTEIPPAL ISLGEGLITA GAQLVELDLS DNAFGPDGVQ 120
GFEALLKSSA CFTLQELKLN NCGMGIGGGK VIGTLEEVHM PQNGINHPGI TALAQAFAVN 180
PLLRVINLND NTFTEKGAVA MAETLKTLRQ VEVINFGDCL VRSKGAVAIA DAIRGGLPKL 240
KELNLSFCEI KRDAALAVAE AMADKAELEK LDLNGNTLGE EGCEQLQEVL EGFNMAKVLA 300
SLSDDEDEEE EEEGEEEEEE AEEEEEEDEE EEEEEEEEEE EEPQQRGQGE KSATPSRKIL 360
DPNTGEPAPV LSSPPPADVS TFLAFPSPEK LLRLGPKSSV LIAQQTDTSD PEKVVSAFLK 420
VSSVFKDEAT VRMAVQDAVD ALMQKAFNSS SFNSNTFLTR LLVHMGLLKS EDKVKAIANL 480
YGPLMALNHM VQQDYFPKAL APLLLAFVTK PNSALESCSF ARHSLLQTLY KV 532 
Gene Ontology
 GO:0005098; F:Ran GTPase activator activity; IEA:InterPro.
 GO:0032853; P:positive regulation of Ran GTPase activity; IEA:GOC.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR009109; Ran_GTPase_activating_1_C.
 IPR027038; RanGap. 
Pfam
 PF07834; RanGAP1_C 
SMART
  
PROSITE
  
PRINTS