CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010790
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-1 complex subunit mu-1-I 
Protein Synonyms/Alias
 Clathrin assembly protein complex 1 medium chain; Clathrin coat assembly protein AP54; Clathrin coat-associated protein AP54; Golgi adaptor AP-1 54 kDa protein; HA1 54 kDa subunit; Mu(1)-adaptin; Mu1-I-adaptin 
Gene Name
 APM1 
Gene Synonyms/Alias
 YAP54; YPL259C; P0394 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
253DNNTETDKKPSITSSubiquitination[1]
254NNTETDKKPSITSSSubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin. AP57 is probably a subunit of the Golgi membrane adaptor. 
Sequence Annotation
 DOMAIN 175 473 MHD.  
Keyword
 Coated pit; Complete proteome; Cytoplasmic vesicle; Membrane; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
MASAVYFCDH NGKPLLSRRY RDDIPLSAID KFPILLSDLE EQSNLIPPCL NHNGLEYLFI 60
QHNDLYVVAI VTSLSANAAA IFTFLHKLVE VLSDYLKTVE EESIRDNFVI IYELLDEVMD 120
YGIPQITETK MLKQYITQKS FKLVKSAKKK RNATRPPVAL TNSVSWRPEG ITHKKNEAFL 180
DIVESINMLM TQKGQVLRSE IIGDVKVNSK LSGMPDLKLG INDKGIFSKY LDDDTNIPSA 240
SATTSDNNTE TDKKPSITSS SATNKKKVNI ELEDLKFHQC VRLSKFENEK IITFIPPDGK 300
FDLMNYRLST TIKPLIWCDV NVQVHSNSRI EIHCKAKAQI KRKSTATNVE ILIPVPDDAD 360
TPTFKYSHGS LKYVPEKSAI LWKIRSFPGG KEYSMSAELG LPSISNNEDG NRTMPKSNAE 420
ILKGPVQIKF QIPYFTTSGI QVRYLKINEP KLQYKSYPWV RYITQSGDDY TIRLT 475 
Gene Ontology
 GO:0030121; C:AP-1 adaptor complex; IPI:SGD.
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0030276; F:clathrin binding; ISS:SGD.
 GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR022775; AP_mu_sigma_su.
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 
Pfam
 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 
SMART
  
PROSITE
 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 
PRINTS
 PR00314; CLATHRINADPT.