UniProt Accession

 D3YX15_MOUSE; D3YX15 

Genbank Protein ID

 AL645723 

Genbank Nucleotide ID

  

Protein Name

 Iodothyronine deiodinase 

Protein Synonyms/Alias

  

Gene Name

 Dio1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
181	GRICYKGKAGPWNYN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Oxidoreductase; Reference proteome; Selenocysteine; Thyroid hormones biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0008430; F:selenium binding; IDA:MGI.
 GO:0004800; F:thyroxine 5'-deiodinase activity; IDA:MGI.
 GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR000643; Iodothyronine_deiodinase. 

Pfam

 PF00837; T4_deiodinase 

SMART

  

PROSITE

  

PRINTS