| Tag | Content |
|---|
| CPLM ID | CPLM-006010 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Trehalose-6-phosphate phosphatase |
Protein Synonyms/Alias | TPP; Osmoregulatory trehalose synthesis protein B; Trehalose 6-phosphate phosphatase; Trehalose-phosphatase |
Gene Name | otsB |
Gene Synonyms/Alias | b1897; JW1886 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 72 | VELDALAKPYRFPLA | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Removes the phosphate from trehalose 6-phosphate (Tre6P) to produce free trehalose. Also catalyzes the dephosphorylation of glucose-6-phosphate (Glu6P) and 2-deoxyglucose-6-phosphate (2dGlu6P). |
Sequence Annotation | REGION 20 22 Substrate (By similarity).
ACT_SITE 20 20 Nucleophile (By similarity).
METAL 20 20 Magnesium (By similarity).
METAL 22 22 Magnesium (By similarity).
METAL 198 198 Magnesium (By similarity). |
Keyword | Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 266 AA |
Protein Sequence | MTEPLTETPE LSAKYAWFFD LDGTLAEIKP HPDQVVVPDN ILQGLQLLAT ASDGALALIS 60
GRSMVELDAL AKPYRFPLAG VHGAERRDIN GKTHIVHLPD AIARDISVQL HTVIAQYPGA 120
ELEAKGMAFA LHYRQAPQHE DALMTLAQRI TQIWPQMALQ QGKCVVEIKP RGTSKGEAIA 180
AFMQEAPFIG RTPVFLGDDL TDESGFAVVN RLGGMSVKIG TGATQASWRL AGVPDVWSWL 240
EMITTALQQK RENNRSDDYE SFSRSI 266 |
Gene Ontology | GO:0000287; F:magnesium ion binding; IDA:UniProtKB. GO:0004805; F:trehalose-phosphatase activity; IDA:EcoCyc. GO:0006970; P:response to osmotic stress; IEP:EcoCyc. GO:0005992; P:trehalose biosynthetic process; IMP:EcoCyc. GO:0070415; P:trehalose metabolism in response to cold stress; IEP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |