| Tag | Content |
|---|
| CPLM ID | CPLM-023514 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transient receptor potential cation channel subfamily V member 2 |
Protein Synonyms/Alias | TrpV2; Osm-9-like TRP channel 2; OTRPC2; Stretch-activated channel 2B; Vanilloid receptor-like protein 1; VRL-1 |
Gene Name | Trpv2 |
Gene Synonyms/Alias | Sac2b; Vrl1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 307 | KLAAKEGKIEIFRHI | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity). |
Sequence Annotation | REPEAT 73 115 ANK 1.
REPEAT 116 162 ANK 2.
REPEAT 163 208 ANK 3.
REPEAT 209 244 ANK 4.
REPEAT 245 293 ANK 5.
REPEAT 294 320 ANK 6.
REGION 1 390 Required for interaction with SLC50A1.
MOD_RES 15 15 Phosphoserine (By similarity).
MOD_RES 47 47 Phosphoserine (By similarity).
MOD_RES 760 760 Phosphoserine (By similarity).
CARBOHYD 571 571 N-linked (GlcNAc...) (Potential).
CARBOHYD 572 572 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; ANK repeat; Calcium; Calcium channel; Calcium transport; Cell membrane; Complete proteome; Cytoplasm; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 761 AA |
Protein Sequence | MTSASSPPAF RLETSDGDEE GNAEVNKGKQ EPPPMESPFQ REDRNSSPQI KVNLNFIKRP 60
PKNTSAPSQQ EPDRFDRDRL FSVVSRGVPE ELTGLLEYLR WNSKYLTDSA YTEGSTGKTC 120
LMKAVLNLQD GVNACIMPLL QIDKDSGNPK LLVNAQCTDE FYQGHSALHI AIEKRSLQCV 180
KLLVENGADV HLRACGRFFQ KHQGTCFYFG ELPLSLAACT KQWDVVTYLL ENPHQPASLE 240
ATDSLGNTVL HALVMIADNS PENSALVIHM YDGLLQMGAR LCPTVQLEEI SNHQGLTPLK 300
LAAKEGKIEI FRHILQREFS GPYQPLSRKF TEWCYGPVRV SLYDLSSVDS WEKNSVLEII 360
AFHCKSPNRH RMVVLEPLNK LLQEKWDRLV SRFFFNFACY LVYMFIFTVV AYHQPSLDQP 420
AIPSSKATFG ESMLLLGHIL ILLGGIYLLL GQLWYFWRRR LFIWISFMDS YFEILFLLQA 480
LLTVLSQVLR FMETEWYLPL LVLSLVLGWL NLLYYTRGFQ HTGIYSVMIQ KVILRDLLRF 540
LLVYLVFLFG FAVALVSLSR EARSPKAPED NNSTVTEQPT VGQEEEPAPY RSILDASLEL 600
FKFTIGMGEL AFQEQLRFRG VVLLLLLAYV LLTYVLLLNM LIALMSETVN HVADNSWSIW 660
KLQKAISVLE MENGYWWCRR KKHREGRLLK VGTRGDGTPD ERWCFRVEEV NWAAWEKTLP 720
TLSEDPSGPG ITGNKKNPTS KPGKNSASEE DHLPLQVLQS P 761 |
Gene Ontology | GO:0044295; C:axonal growth cone; IEA:Compara. GO:0044297; C:cell body; IEA:Compara. GO:0009986; C:cell surface; IEA:Compara. GO:0012505; C:endomembrane system; IDA:UniProtKB. GO:0032584; C:growth cone membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0042470; C:melanosome; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW. GO:0045773; P:positive regulation of axon extension; IEA:Compara. GO:0090280; P:positive regulation of calcium ion import; IEA:Compara. GO:0009408; P:response to heat; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |