| Tag | Content |
|---|
| CPLM ID | CPLM-016107 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phospholipase DDHD2 |
Protein Synonyms/Alias | DDHD domain-containing protein 2; SAM, WWE and DDHD domain-containing protein 1 |
Gene Name | Ddhd2 |
Gene Synonyms/Alias | Kiaa0725; Samwd1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 75 | EDAYGSGKDCNERIV | ubiquitination | [1] | | 375 | IGDIDSEKGSLSSAE | ubiquitination | [1] | | 576 | TRMSMDLKNNLLGSL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4- phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity). |
Sequence Annotation | DOMAIN 30 112 WWE.
DOMAIN 383 445 SAM.
DOMAIN 484 688 DDHD.
ACT_SITE 351 351 Probable.
MOD_RES 447 447 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Golgi apparatus; Hydrolase; Lipid degradation; Lipid metabolism; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 699 AA |
Protein Sequence | MSSGESHQEQ LSQSDPSPSP NSCSSFELID MDASSSYEPV SPHWFYCKVL DSKELWIPFN 60
SEDSQQLEDA YGSGKDCNER IVPTDGGRYD VHLGERMRYA VYWDELPSEV RRCTWFYKGD 120
KDNKYVPYSE SFSQVLEDTY MLAVTLDEWK KKIESPNREI IVLHNPKLMV HYQPIAGSDE 180
WGSTSTEQGR PRSVKRGVEN IPVDIHCGEP LQIDHLVFVV HGIGPACDLR FRSIVQCVND 240
FRSVSLNLLQ THFKKAQENE QIGRVEFLPV NWHSPLHSTG VDIDLQRITL PSINRLRHFT 300
NDTILDVFFY NSPTYCQTIV DTVASEMNRI YTLFLQRNPD FKGGVSIAGH SLGSLILFDI 360
LTNQKNSIGD IDSEKGSLSS AEDRGDASTL EEDLKKLQLS EFVTVFEKEK VDREALALCT 420
DRDLQEMGIP LGPRKKILNH FSARKNSVSI NRPAMSASEV NISKENGDYL DVGIGQVSVK 480
YPRLNYKPEI FFAFGSPIGM FLTVRGLRRI DPNYKFPTCK GFFNIYHPFD PVAYRIEPMV 540
APGIEFEPML IPHHKGRKRM HLELREGLTR MSMDLKNNLL GSLRMAWKSF TRGPYPALQA 600
SETAEETEAE PESSSEKSNE ANTEEPPVEV KEEAPISVGM LNGGQRIDYV LQEKPIESFN 660
EYLFALQSHL CYWESEDTVL LVLKEIYQTQ GVFLDQPLQ 699 |
Gene Ontology | GO:0005813; C:centrosome; IEA:Compara. GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:InterPro. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |