UniProt Accession

 CATB_HUMAN; P07858; B3KQR5; B3KRR5; Q503A6; Q96D87 

Genbank Protein ID

 M14221; L16510; AK092070; AK075393; CH471157; BC010240; BC095408; M13230 

Genbank Nucleotide ID

 AAA52129.1; AAC37547.1; BAG52477.1; BAG52127.1; EAW65630.1; AAH10240.1; AAH95408.1; AAA52125.1 

Protein Name

 Cathepsin B 

Protein Synonyms/Alias

 APP secretase; APPS; Cathepsin B1; Cathepsin B light chain; Cathepsin B heavy chain 

Gene Name

 CTSB 

Gene Synonyms/Alias

 CPSB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
220	PGYSPTYKQDKHYGY	ubiquitination	[1, 2]
223	SPTYKQDKHYGYNSY	ubiquitination	[1, 2]
237	YSVSNSEKDIMAEIY	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. 

Sequence Annotation

 ACT_SITE 108 108
 ACT_SITE 278 278
 ACT_SITE 298 298
 CARBOHYD 192 192 N-linked (GlcNAc...).
 DISULFID 93 122
 DISULFID 105 150
 DISULFID 141 207
 DISULFID 142 146
 DISULFID 179 211
 DISULFID 187 198  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Polymorphism; Protease; Reference proteome; Secreted; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0036021; C:endolysosome lumen; TAS:Reactome.
 GO:0005615; C:extracellular space; ISS:BHF-UCL.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0004197; F:cysteine-type endopeptidase activity; IDA:BHF-UCL.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:UniProtKB.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0006508; P:proteolysis; IDA:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.
 GO:0050790; P:regulation of catalytic activity; IEA:InterPro.
 GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR015643; Peptidase_C1A_cathepsin-B.
 IPR012599; Propeptide_C1A. 

Pfam

 PF00112; Peptidase_C1
 PF08127; Propeptide_C1 

SMART

 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.