CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007934
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Testin 
Protein Synonyms/Alias
 TES1/TES2 
Gene Name
 Tes 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
225APAAVASKDKSAESKacetylation[1]
300RHYCDSEKPRCAGCDubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity). 
Sequence Annotation
 DOMAIN 97 204 PET.
 DOMAIN 236 299 LIM zinc-binding 1.
 DOMAIN 301 361 LIM zinc-binding 2.
 DOMAIN 364 423 LIM zinc-binding 3.  
Keyword
 Alternative splicing; Cell junction; Complete proteome; Cytoplasm; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MSATHPTRLG TRTKESNACA SQGLVRKPPW ANEGEGFELH FWRKICRNCN VVKKSMTVLL 60
SNEEDRKVGR LFEDTKYTTL IAKLKSDGIP MYKRNVMILT NPVAAKKNVS INTVTYEWAP 120
PVQNQALARQ YMQMLPKEKQ PVAGSEGAQY RKKQLAKQLP AHDQDPSKCH ELSPKEVKEM 180
EQFVKKYKSE ALGVGDVKFP SEMNAQGDKV HNCGNRHAPA AVASKDKSAE SKKTQYSCYC 240
CKHTTNEGEP AIYAERAGYD KLWHPACFIC STCGELLVDM IYFWKNGKLY CGRHYCDSEK 300
PRCAGCDELI FSNEYTQAEN QNWHLKHFCC FDCDHILAGK IYVMVTDKPV CKPCYVKNHA 360
VVCQGCHNAI DPEVQRVTYN NFSWHASTEC FLCSCCSKCL IGQKFMPVEG MVFCSVECKR 420
MMS 423 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB. 
Interpro
 IPR010442; PET_domain.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM
 PF06297; PET 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS51303; PET 
PRINTS