| Tag | Content |
|---|
| CPLM ID | CPLM-006702 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Anaerobic nitric oxide reductase transcription regulator NorR |
Protein Synonyms/Alias | |
Gene Name | norR |
Gene Synonyms/Alias | ygaA; b2709; JW5843 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 61 | LAIDGLAKDVLGRRF | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. Not required for induction of the aerobic NO-detoxifying enzyme NO dioxygenase. Binds to the promoter region of norVW, to a consensus target sequence, GT-(N7)-AC, which is highly conserved among proteobacteria. |
Sequence Annotation | DOMAIN 187 416 Sigma-54 factor interaction.
NP_BIND 215 222 ATP (Potential).
NP_BIND 278 287 ATP (Potential).
DNA_BIND 479 498 H-T-H motif (By similarity).
REGION 1 186 NO sensor or transducer (Probable).
MOD_RES 57 57 4-aspartylphosphate (By similarity). |
Keyword | ATP-binding; Complete proteome; DNA-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 504 AA |
Protein Sequence | MSFSVDVLAN IAIELQRGIG HQDRFQRLIT TLRQVLECDA SALLRYDSRQ FIPLAIDGLA 60
KDVLGRRFAL EGHPRLEAIA RAGDVVRFPA DSELPDPYDG LIPGQESLKV HACVGLPLFA 120
GQNLIGALTL DGMQPDQFDV FSDEELRLIA ALAAGALSNA LLIEQLESQN MLPGDATPFE 180
AVKQTQMIGL SPGMTQLKKE IEIVAASDLN VLISGETGTG KELVAKAIHE ASPRAVNPLV 240
YLNCAALPES VAESELFGHV KGAFTGAISN RSGKFEMADN GTLFLDEIGE LSLALQAKLL 300
RVLQYGDIQR VGDDRCLRVD VRVLAATNRD LREEVLAGRF RADLFHRLSV FPLSVPPLRE 360
RGDDVILLAG YFCEQCRLRQ GLSRVVLSAG ARNLLQHYSF PGNVRELEHA IHRAVVLARA 420
TRSGDEVILE AQHFAFPEVT LPTPEVAAVP VVKQNLREAT EAFQRETIRQ ALAQNHHNWA 480
ACARMLETDV ANLHRLAKRL GLKD 504 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:HAMAP. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:HAMAP. GO:0000160; P:phosphorelay signal transduction system; IEA:HAMAP. GO:0007600; P:sensory perception; IEA:HAMAP. GO:0006351; P:transcription, DNA-dependent; IDA:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |