UniProt Accession

 F2Z471_MOUSE; F2Z471 

Genbank Protein ID

 AL645589; AL713864 

Genbank Nucleotide ID

  

Protein Name

 Voltage-dependent anion-selective channel protein 1 

Protein Synonyms/Alias

  

Gene Name

 Vdac1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	PTYADLGKSARDVFT	acetylation	[1]
20	SARDVFTKGYGFGLI	acetylation	[1, 2, 3, 4, 5, 6]
20	SARDVFTKGYGFGLI	phosphoglycerylation	[7]
20	SARDVFTKGYGFGLI	succinylation	[1]
20	SARDVFTKGYGFGLI	ubiquitination	[8]
28	GYGFGLIKLDLKTKS	acetylation	[1, 2, 4, 5, 6]
28	GYGFGLIKLDLKTKS	ubiquitination	[8]
34	IKLDLKTKSENGLEF	ubiquitination	[8]
53	SANTETTKVNGSLET	ubiquitination	[8]
61	VNGSLETKYRWTEYG	acetylation	[5, 6]
61	VNGSLETKYRWTEYG	ubiquitination	[8]
96	DQLARGLKLTFDSSF	acetylation	[5, 6]
109	SFSPNTGKKNAKIKT	acetylation	[1, 5, 6]
109	SFSPNTGKKNAKIKT	succinylation	[1]
109	SFSPNTGKKNAKIKT	ubiquitination	[8]
197	FGGSIYQKVNKKLET	acetylation	[4, 6]
197	FGGSIYQKVNKKLET	ubiquitination	[8]
201	IYQKVNKKLETAVNL	acetylation	[5]
224	TRFGIAAKYQVDPDA	acetylation	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [6] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [7] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [8] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 254 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; ISO:MGI.
 GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro.
 GO:0001662; P:behavioral fear response; IMP:MGI.
 GO:0007612; P:learning; IMP:MGI.
 GO:0007270; P:neuron-neuron synaptic transmission; IMP:MGI. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

  

PRINTS

 PR00185; EUKARYTPORIN.