CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016980
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein AHNAK2 
Protein Synonyms/Alias
  
Gene Name
 AHNAK2 
Gene Synonyms/Alias
 C14orf78; KIAA2019 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
149LKDSSAAKLFNLREGubiquitination[1]
185LQYSEPYKVQFKIRRubiquitination[1]
231GCRETPTKTLEGDGDubiquitination[2]
245DQERLISKPRVGRGRubiquitination[2]
322PGSQRRRKFLNLRFRubiquitination[3]
989GDLSLADKDVTAKDSacetylation[4]
989GDLSLADKDVTAKDSubiquitination[2]
1510FGVSAPGKSIEASVDacetylation[5]
2097QVDIKGPKLDLKDPKubiquitination[2, 6]
2101KGPKLDLKDPKVEMRubiquitination[2]
2104KLDLKDPKVEMRVPDubiquitination[2, 6]
5191YSQESWFKMPKFRMPubiquitination[3]
5194ESWFKMPKFRMPSLRubiquitination[3]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 DOMAIN 112 193 PDZ.
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 294 294 Phosphoserine.
 MOD_RES 593 593 Phosphoserine.
 MOD_RES 842 842 Phosphoserine.
 MOD_RES 1007 1007 Phosphoserine.
 MOD_RES 1112 1112 Phosphoserine.
 MOD_RES 1337 1337 Phosphoserine.
 MOD_RES 1502 1502 Phosphoserine.
 MOD_RES 1510 1510 N6-acetyllysine.
 MOD_RES 1667 1667 Phosphoserine.
 MOD_RES 1832 1832 Phosphoserine.
 MOD_RES 1840 1840 N6-acetyllysine.
 MOD_RES 2162 2162 Phosphoserine.
 MOD_RES 2492 2492 Phosphoserine.
 MOD_RES 2500 2500 N6-acetyllysine.
 MOD_RES 2822 2822 Phosphoserine.
 MOD_RES 2987 2987 Phosphoserine.
 MOD_RES 3152 3152 Phosphoserine.
 MOD_RES 3408 3408 Phosphoserine.
 MOD_RES 3812 3812 Phosphoserine.
 MOD_RES 3977 3977 Phosphoserine.
 MOD_RES 4142 4142 Phosphoserine.
 MOD_RES 4307 4307 Phosphoserine.
 MOD_RES 4472 4472 Phosphoserine.
 MOD_RES 4477 4477 Phosphoserine.
 MOD_RES 4894 4894 Phosphoserine.
 MOD_RES 4897 4897 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5795 AA 
Protein Sequence
MCDCFHMVLP TWPGTPGSVS GRQLQPGEPG AETEDDHSVT EGPADEGIRP RPQGSSPVYE 60
YTTEAADFGL QEDAPGRQGS AGRRRSWWKR DSGDSRTFFR MSRPEAVQEA TEVTLKTEVE 120
AGASGYSVTG GGDQGIFVKQ VLKDSSAAKL FNLREGDQLL STTVFFENIK YEDALKILQY 180
SEPYKVQFKI RRQLPAPQDE EWASSDAQHG PQGKEKEDTD VADGCRETPT KTLEGDGDQE 240
RLISKPRVGR GRQSQRERLS WPKFQSIKSK RGPGPQRSHS SSEAYEPRDA HDVSPTSTDT 300
EAQLTVERQE QKAGPGSQRR RKFLNLRFRT GSGQGPSSTG QPGRGFQSGV GRAGVLEELG 360
PWGDSLEETG AATGSRREER AEQDREVMPA QSMPLPTELG DPRLCEGTPQ EGGLRAARLH 420
GKTLEGQAQE TAVAQRKPRA QPTPGMSREG EGEGLQSLEI GIARLSLRDT TEGGTQIGPP 480
EIRVRVHDLK TPKFAFSTEK EPERERRLST PQRGKRQDAS SKAGTGLKGE EVEGAGWMPG 540
REPTTHAEAQ GDEGDGEEGL QRTRITEEQD KGREDTEGQI RMPKFKIPSL GWSPSKHTKT 600
GREKATEDTE QGREGEATAT ADRREQRRTE EGLKDKEDSD SMTNTTKIQL IHDEKRLKKE 660
QILTEKEVAT KDSKFKMPKF KMPLFGASAP GKSMEASVDV SAPKVEADVS LLSMQGDLKT 720
TDLSVQTPSA DLEVQDGQVD VKLPEGPLPE GASLKGHLPK VQRPSLKMPK VDLKGPKLDL 780
KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKEVTAKD SKFKMPKFKM 840
PSFGVSAPGK SMEDSVDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAGQVDVK 900
LPEGPVPEGA GPKVHLPKVE MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDGEVS 960
LPSMEVDVQA QKAKLDGAWL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIKAL 1020
VDVSAPKVEA DLSLPSMQGD LKTTDLSIQP ASTDLKVQAD QVDVKLPEGH LPEGAGLKGH 1080
LPKVEMPSFK MPKVALKGPQ VDVKGPKLDL KSPKAEVTAP DVEVSLPSVE VDVEAPGAKL 1140
DSARLEGELS LADKDVTAKD SRFKMPKFKM PSFGASAPGK SIEASVDVSA PKVEADVSLP 1200
SMQGDLKTTD LSIQPPSADL EVHAGQVDVK LLEGHVPEGA GFKGHLPKVQ MPSLKMPKVD 1260
LKGPQVEVRG PKLDLKGHKA EVTAHEVAVS LPSVEVDMQA PGAKLDGAQL DGDLSLADKD 1320
VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS VDLSAPKVEA DMSLPSMQGD LKTTDLSIQP 1380
PSTDLELQAG QLDVKLPEGP VPEGAGLKGH LPKLQMPSFK VPKVDLKGPE IDIKGPKLDL 1440
KDPKVEVTAP DVEVSLPSVE VDVEAPGAKL DGGRLEEDMS LADKDLTTKD SKFKMPKFKM 1500
PSFGVSAPGK SIEASVDVSA PKVEADVSLP SMQGDLKATD LSIQPPSADL EVQAGQVDVK 1560
LPEGPVSEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKV EVTAPDVKMS 1620
LSSMEVDVQA PRAKLDGAQL EGDLSLADKA VTAKDSKFKM PKFKMPSFGV SAPGKSIEAS 1680
VDVSEPKVEA DVSLPSMQGD LKTTDLSIQS PSADLEVQAG QVNVKLPEGP LPEGAGFKGH 1740
LPKVQMPSLK MPKVALKGPQ MDVKGPKLDL KGPKAEVMAP DVEVSLPSVE VDVEAPGAKL 1800
DSVRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVDVSA PKVEAEVSLP 1860
SMQGDLKTTD LCIPLPSADL VVQAGQVDMK LPEGQVPEGA GLKGHLPKVD MPSFKMPKVD 1920
LKGPQTDVKG AKLDLKGPKA EVTAPDVEVS LPSMEVDVQA QKAKLDGARL EGDLSLADKD 1980
MTAKDSKFKM PKFKMPSFGV SAPGRSIEAS VDVPAPKVEA DVSLPSMQGD LKTTDLSIQP 2040
PSADLKVQTG QVDVKLPEGH VPEGAGLKGH LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL 2100
KDPKVEMRVP DVEVSLPSME VDVQAPRAKL DSAHLQGDLT LANKDLTTKD SKFKMPKFKM 2160
PSFGVSAPGK SIEASVDVSP PKVEADMSLP SMQGDLKTTD LSIQPLSADV KVQAGQVDVK 2220
LLEGPVPEEV GLKGHLPKLQ MPSFKVPKVD LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS 2280
LPSVEVDVKA PGAKLDGARL EGDMSLADKD VTAKDSKFKM PKFKMLSFGV SALGKSIEAS 2340
ADVSALKVEA DVSLPSMQGD LKTTDLSVQP PSADLEVQAG QVDVKLPEGP VPEGAGLKGH 2400
LPKLQMPSFK MPKVDLKGPQ IDVKGPKLDL KGPKTDVMAP DVEVSQPSVE VDVEAPGAKL 2460
DGAWLEGDLS VADKDVTTKD SRFKIPKFKM PSFGVSAPGK SIEASVDVSA PKVEADGSLS 2520
SMQGDLKATD LSIQPPSADL EVQAGQVDVK LPEGPVPEGA GLKGHLPKVQ MPSFKMPEMD 2580
LKGPQLDVKG PKLDLKGPKA EVTAPDVEMS LSSMEVDVQA PRAKLDGARL EGDLSLADKG 2640
VTAKDSKFKM PKFKMPSFRV SAPGESIEAL VDVSELKVEA DMSLPSMQGD LKTTDISIQP 2700
PSAQLEVQAG QVDVKLPEGH VPEGAGLKGH LPKLQMPSFK MPEVDLKGPQ IDVKGPNVDL 2760
KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGARLEGDLS LADKGMTAKD SKFKMPKFKM 2820
PSFGVSAPGK SIEASVDVSE LKVEADGSFP SMQGDLKTTD IRIQPPSAQL EVQAGQVDVK 2880
LPEGHVPEGA GLKGHLPKVQ MPSFKMPKVD LKGPQIDVKG PKLDLKGPKA EVTAPDVEVS 2940
LPSVEVDVEA PRAKLDGARL EGDLSLADKD VTAKDSKFKM PKFKMPSFGV SAPGKSIEVS 3000
VDVSAPKVEA EVSLPSMQGD LKTTDISIEP PSAQLEVQAG QVDLKLPEGH VPEGAGLKGH 3060
LPKLQMPSFK MPKVDRKGPQ IDVKGPKLDL KGPKTDVTAP DVEVSQPGME VDVEAPGAKL 3120
DGARLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEVLVDVSA PKVEADLSLP 3180
SMQGDLKNTD ISIEPPSAQL EVQAGQVDVK LPEGHVLEGA GLKGHLPKLQ MPSFKMPKVD 3240
RKGPQIDIKG PKLDLKGPKM DVTAPDVEVS QPSMEVDVEA PGAKLDGARL EGDLSLADKD 3300
VTAKDSKFKM PKFKMPSYRA SAPGKSIQAS VDVSAPKAEA DVSLPSMQGD LKTTDLSIQL 3360
PSVDLEVQAG QVDVKLPEGH VPEGAGLKGH LPKVEMPSFK MPKVDLKSPQ VDIKGPKLDL 3420
KVPKAEVTVP DVEVSLPSVE VDVQAPRAKL DGARLEGDLS LAEKDVTAKD SKFKMPKFKM 3480
PSFGVSAPGR SIEASLDVSA PKVEADVSLS SMQGDLKATD LSIQPPSADL EVQAVQVDVE 3540
LLEGPVPEGA GLKGHLPKVE MPSLKTPKVD LKGPQIDVKG PKLDLKGPKA EVRVPDVEVS 3600
LPSVEVDVQA PKAKLDAGRL EGDLSLADKD VTAKDSKFKM PKFKMPSFRV SAPGKSMEAS 3660
VDVSAPKVEA DVSLPSMQGD LKTTDLSIQP PSADLKVQAG QMDVKLPEGQ VPEGAGLKEH 3720
LPKVEMPSLK MPKVDLKGPQ VDIKGPKLDL KVSKAEVTAP DVEVSLPSVE VDVQAPRAKL 3780
DSAQLEGDLS LADKDVTAKD SKFKMPKFKM PSFGVSAPGK SIEASVHVSA PKVEADVSLP 3840
SMQGDLKTTD LSIQPHSADL TVQARQVDMK LLEGHVPEEA GLKGHLPKVQ MPSFKMPKVD 3900
LKGPEIDIKG PKLDLKDPKV EVTAPDVEVS LPSVEVDVEA PGAKLDGARL EGDLSLADKD 3960
MTAKDSKFKM PKFKMPSFGV SAPGKSMEAS VDVTAPKVEA DVSLPSMQGD LKATDLSVQP 4020
PSADLEVQAG QVDVKLPEGP VPEGASLKGH LPKVQMPSFK MPKVDLKGPQ IDVKGPKLDL 4080
KGPKAEVTAP DVKMSLSSME VDVQAPRAKL DGVQLEGDLS LADKDVTAKD SKFKMPKFKM 4140
PSFGVSAPGK SMEASVDVSE LKAKADVSLP SMQGDLKTTD LSIQSPSADL EVQAGQVDVK 4200
LPEGPLPKGA GLKGHLPKVQ MPCLKMPKVA LKGPQVDVKG PKLDLKGPKA DVMTPVVEVS 4260
LPSMEVDVEA PGAKLDSVRL EGDLSLADKD MTAKDSKFKM PKFKMPSFGV SAPGKSIEAS 4320
LDVSALKVEA DVSLPSMQGD LKTTHLSIQP PSADLEVQAG QEDVKLPEGP VHEGAGLKGH 4380
LPKLQMPSFK VPKVDLKGPQ IDVNVPKLDL KGPKVEVTSP NLDVSLPSME VDIQAPGAKL 4440
DSTRLEGDLS LADKDVTAKD SKFKMPKFKM PSFGMLSPGK SIEVSVDVSA PKMEADMSIP 4500
SMQGDLKTTD LRIQAPSADL EVQAGQVDLK LPEGHMPEVA GLKGHLPKVE MPSFKMPKVD 4560
LKGPQVDVKG PKLDLKGPKA EVMAPDVEVS LPSVETDVQA PGSMLDGARL EGDLSLAHED 4620
VAGKDSKFQG PKLSTSGFEW SSKKVSMSSS EIEGNVTFHE KTSTFPIVES VVHEGDLHDP 4680
SRDGNLGLAV GEVGMDSKFK KLHFKVPKVS FSSTKTPKDS LVPGAKSSIG LSTIPLSSSE 4740
CSSFELQQVS ACSEPSMQMP KVGFAGFPSS RLDLTGPHFE SSILSPCEDV TLTKYQVTVP 4800
RAALAPELAL EIPSGSQADI PLPKTECSTD LQPPEGVPTS QAESHSGPLN SMIPVSLGQV 4860
SFPKFYKPKF VFSVPQMAVP EGDLHAAVGA PVMSPLSPGE RVQCPLPSTQ LPSPGTCVSQ 4920
GPEELVASLQ TSVVAPGEAP SEDADHEGKG SPLKMPKIKL PSFRWSPKKE TGPKVDPECS 4980
VEDSKLSLVL DKDEVAPQSA IHMDLPPERD GEKGRSTKPG FAMPKLALPK MKASKSGVSL 5040
PQRDVDPSLS SATAGGSFQD TEKASSDGGR GGLGATASAT GSEGVNLHRP QVHIPSLGFA 5100
KPDLRSSKAK VEVSQPEADL PLPKHDLSTE GDSRGCGLGD VPVSQPCGEG IAPTPEDPLQ 5160
PSCRKPDAEV LTVESPEEEA MTKYSQESWF KMPKFRMPSL RRSFRDRGGA GKLEVAQTQA 5220
PAATGGEAAA KVKEFLVSGS NVEAAMSLQL PEADAEVTAS ESKSSTDILR CDLDSTGLKL 5280
HLSTAGMTGD ELSTSEVRIH PSKGPLPFQM PGMRLPETQV LPGEIDETPL SKPGHDLASM 5340
EDKTEKWSSQ PEGPLKLKAS STDMPSQISV VNVDQLWEDS VLTVKFPKLM VPRFSFPAPS 5400
SEDDVFIPTV REVQCPEANI DTALCKESPG LWGASILKAG AGVPGEQPVD LNLPLEAPPI 5460
SKVRVHIQGA QVESQEVTIH SIVTPEFVDL SVPRTFSTQI VRESEIPTSE IQTPSYGFSL 5520
LKVKIPEPHT QARVYTTMTQ HSRTQEGTEE APIQATPGVD SISGDLQPDT GEPFEMISSS 5580
VNVLGQQTLT FEVPSGHQLA DSCSDEEPAE ILEFPPDDSQ EATTPLADEG RAPKDKPESK 5640
KSGLLWFWLP NIGFSSSVDE TGVDSKNDVQ RSAPIQTQPE ARPEAELPKK QEKAGWFRFP 5700
KLGFSSSPTK KSKSTEDGAE LEEQKLQEET ITFFDARESF SPEEKEEGEL IGPVGTGLDS 5760
RVMVTSAART ELILPEQDRK ADDESKGSGL GPNEG 5795 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR001478; PDZ. 
Pfam
  
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS