UniProt Accession

 ZFAN5_MOUSE; O88878; Q3B7K8 

Genbank Protein ID

 AF062071; AK076397; BC107566; BC119124; BC119126 

Genbank Nucleotide ID

 AAC42600.1; BAC36321.1; AAI07567.1; AAI19125.1; AAI19127.1 

Protein Name

 AN1-type zinc finger protein 5 

Protein Synonyms/Alias

 Zinc finger A20 domain-containing protein 2; Zinc finger protein 216 

Gene Name

 Zfand5 

Gene Synonyms/Alias

 Za20d2; Zfp216; Znf216 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
86	AAGSTSEKSRNVPVA	ubiquitination	[1]
209	NPVVVAEKIQRI***	acetylation	[2, 3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. 

Sequence Annotation

 ZN_FING 8 42 A20-type.
 ZN_FING 151 194 AN1-type.
 MOD_RES 48 48 Phosphoserine (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0060324; P:face development; IMP:MGI.
 GO:0010761; P:fibroblast migration; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:MGI.
 GO:0003016; P:respiratory system process; IMP:MGI.
 GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
 GO:0048745; P:smooth muscle tissue development; IMP:MGI.
 GO:0001944; P:vasculature development; IMP:MGI. 

Interpro

 IPR002653; Znf_A20.
 IPR000058; Znf_AN1. 

Pfam

 PF01754; zf-A20
 PF01428; zf-AN1 

SMART

 SM00259; ZnF_A20
 SM00154; ZnF_AN1 

PROSITE

 PS51036; ZF_A20
 PS51039; ZF_AN1 

PRINTS