CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013810
UniProt Accession
Genbank Protein ID
 AB019489; AB019491; AB019492; AB019493; AB007940; AL049702; AL157958; AK095838; AL021069; AL022171; AL022400; AL031286; AL022171; AL022400; AL031286; AL022171; AL021069; AL022400; AL031286; AL022171; AL022400; AL031286; AL136377; AL161671; AL591108; Z99127; AL022400; AL022171; AL031286; AL022400; AL021069; AL022171; AL031286; AL022400; AL022171; AL031286; AL136377; AL161671; AL591108; Z99127; AL031286; AL022171; AL022400; AL031286; AL021069; AL022171; AL022400; AL031286; AL022171; AL022400; AL136377; AL161671; AL591108; Z99127; AL136377; AL161671; Z99127; AL136377; AL161671; Z99127; AL136377; AL161671; Z99127; AL136377; AL022171; AL022400; AL031286; AL161671; AL591108; Z99127; AL161671; Z99127; AL161671; AL136377; Z99127; AL161671; AL136377; Z99127; AL161671; AL136377; Z99127; AL161671; AL022171; AL022400; AL031286; AL136377; AL591108; Z99127; AL591108; AL022171; AL022400; AL031286; AL136377; AL161671; Z99127; Z99127; AL161671; Z99127; AL136377; AL161671; Z99127; AL136377; AL161671; Z99127; AL136377; AL161671; Z99127; AL022171; AL022400; AL031286; AL136377; AL161671; AL591108; CH471067; CH471067; BC012094; BC018630; BC041888; AY364260 
Genbank Nucleotide ID
 BAA77330.1; BAA77332.1; BAA77333.2; BAA77334.1; BAA32316.2; CAB41266.1; CAB76100.1; BAC04635.1; CAI23486.1; CAI23486.1; CAI23486.1; CAI23486.1; CAI20382.1; CAI20382.1; CAI20382.1; CAI20383.1; CAI20383.1; CAI20383.1; CAI20383.1; CAI20384.1; CAI20384.1; CAI20384.1; CAI20384.1; CAI20384.1; CAI20384.1; CAI20384.1; CAI22876.1; CAI22876.1; CAI22876.1; CAI22877.1; CAI22877.1; CAI22877.1; CAI22877.1; CAI22878.1; CAI22878.1; CAI22878.1; CAI22878.1; CAI22878.1; CAI22878.1; CAI22878.1; CAI22380.1; CAI22380.1; CAI22380.1; CAI22381.1; CAI22381.1; CAI22381.1; CAI22381.1; CAI22382.1; CAI22382.1; CAI22382.1; CAI22382.1; CAI22382.1; CAI22382.1; CAI22382.1; CAI22932.1; CAI22932.1; CAI22932.1; CAI22933.1; CAI22933.1; CAI22933.1; CAI22934.1; CAI22934.1; CAI22934.1; CAI22935.1; CAI22935.1; CAI22935.1; CAI22935.1; CAI22935.1; CAI22935.1; CAI22935.1; CAI16277.1; CAI16277.1; CAI16278.1; CAI16278.1; CAI16278.1; CAI16279.1; CAI16279.1; CAI16279.1; CAI16280.1; CAI16280.1; CAI16280.1; CAI16281.1; CAI16281.1; CAI16281.1; CAI16281.1; CAI16281.1; CAI16281.1; CAI16281.1; CAH70225.1; CAH70225.1; CAH70225.1; CAH70225.1; CAH70225.1; CAH70225.1; CAH70225.1; CAI18933.1; CAI18933.1; CAI18934.1; CAI18934.1; CAI18934.1; CAI18935.1; CAI18935.1; CAI18935.1; CAI18936.1; CAI18936.1; CAI18936.1; CAI18937.1; CAI18937.1; CAI18937.1; CAI18937.1; CAI18937.1; CAI18937.1; CAI18937.1; EAW90977.1; EAW90979.1; AAH12094.1; AAH18630.2; AAH41888.1; AAQ76819.1 
Protein Name
 Rab GTPase-activating protein 1-like 
Protein Synonyms/Alias
  
Gene Name
 RABGAP1L 
Gene Synonyms/Alias
 HHL; KIAA0471 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
570RYRILITKDSAQESVubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 DOMAIN 126 282 PID.
 DOMAIN 538 724 Rab-GAP TBC.
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 471 471 Phosphothreonine.
 MOD_RES 480 480 Phosphoserine.
 MOD_RES 490 490 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome; Ribosomal frameshifting. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 815 AA 
Protein Sequence
MEVRASLQKV SGSSDSVATM NSEEFVLVPQ YADDNSTKHE EKPQLKIVSN GDEQLEKAME 60
EILRDSEKRP SSLLVDCQSS SEISDHSFGD IPASQTNKPS LQLILDPSNT EISTPRPSSP 120
GGLPEEDSVL FNKLTYLGCM KVSSPRNEVE ALRAMATMKS SSQYPFPVTL YVPNVPEGSV 180
RIIDQSSNVE IASFPIYKVL FCARGHDGTT ESNCFAFTES SHGSEEFQIH VFSCEIKEAV 240
SRILYSFCTA FKRSSRQVSD VKDSVIPTPD SDVFTFSVSL EVKEDDGKGN FSPVPKDRDK 300
FYFKLKQGIE KKVVITVQQL SNKELAIERC FGMLLSPGRN VKNSDMHLLD MESMGKSYDG 360
RAYVITGMWN PNAPVFLALN EETPKDKQVY MTVAVDMVVT EVVEPVRFLL ETVVRVYPAN 420
ERFWYFSRKT FTETFFMRLK QSEGKGHTNA GDAIYEVVSL QRESDKEEPV TPTSGGGPMS 480
PQDDEAEEES DNELSSGTGD VSKDCPEKIL YSWGELLGKW HSNLGARPKG LSTLVKSGVP 540
EALRAEVWQL LAGCHDNQAM LDRYRILITK DSAQESVITR DIHRTFPAHD YFKDTGGDGQ 600
ESLYKICKAY SVYDEDIGYC QGQSFLAAVL LLHMPEEQAF CVLVKIMYDY GLRDLYRNNF 660
EDLHCKFYQL ERLMQEQLPD LHSHFSDLNL EAHMYASQWF LTLFTAKFPL CMVFHIIDLL 720
LCEGLNIIFH VALALLKTSK EDLLQADFEG ALKFFRVQLP KRYRAEENAR RLMEQACNIK 780
VPTKKLKKYE KEYQTMRESQ LQQEDPMDRY KFVYL 815 
Gene Ontology
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005097; F:Rab GTPase activator activity; IDA:MGI.
 GO:0017137; F:Rab GTPase binding; IDA:BHF-UCL.
 GO:0032880; P:regulation of protein localization; IDA:MGI. 
Interpro
 IPR022164; Kinesin-like.
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF12473; DUF3694
 PF00640; PID
 PF00566; RabGAP-TBC 
SMART
 SM00462; PTB
 SM00164; TBC 
PROSITE
 PS01179; PID
 PS50086; TBC_RABGAP 
PRINTS