UniProt Accession

 CALRL_RAT; Q63118 

Genbank Protein ID

 X70658 

Genbank Nucleotide ID

 CAA49997.1 

Protein Name

 Calcitonin gene-related peptide type 1 receptor 

Protein Synonyms/Alias

 CGRP type 1 receptor; Calcitonin receptor-like receptor 

Gene Name

 Calcrl 

Gene Synonyms/Alias

 Cgrpr 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
455	DIENVALKPEKMYDL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). 

Sequence Annotation

 CARBOHYD 30 30 N-linked (GlcNAc...) (Potential).
 CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
 CARBOHYD 118 118 N-linked (GlcNAc...) (Potential).
 CARBOHYD 123 123 N-linked (GlcNAc...) (Potential).
 CARBOHYD 128 128 N-linked (GlcNAc...) (Potential).
 CARBOHYD 129 129 N-linked (GlcNAc...) (Potential).
 DISULFID 48 74 By similarity.
 DISULFID 65 105 By similarity.
 DISULFID 88 127 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 464 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005768; C:endosome; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005764; C:lysosome; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0001605; F:adrenomedullin receptor activity; IEA:Compara.
 GO:0001635; F:calcitonin gene-related polypeptide receptor activity; IEA:Compara.
 GO:0004948; F:calcitonin receptor activity; IMP:RGD.
 GO:0008565; F:protein transporter activity; IEA:Compara.
 GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0006171; P:cAMP biosynthetic process; IEA:Compara.
 GO:0071329; P:cellular response to sucrose stimulus; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IMP:RGD.
 GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0031623; P:receptor internalization; IEA:Compara.
 GO:0006937; P:regulation of muscle contraction; IMP:RGD. 

Interpro

 IPR003287; GCPR_2_calcitonin_rcpt_fam.
 IPR017981; GPCR_2-like.
 IPR003289; GPCR_2_CGRP1_rcpt.
 IPR001879; GPCR_2_extracellular_dom.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS. 

Pfam

 PF00002; 7tm_2
 PF02793; HRM 

SMART

 SM00008; HormR 

PROSITE

 PS00649; G_PROTEIN_RECEP_F2_1
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50227; G_PROTEIN_RECEP_F2_3
 PS50261; G_PROTEIN_RECEP_F2_4 

PRINTS

 PR01351; CGRPRECEPTOR.
 PR01350; CTRFAMILY.
 PR00249; GPCRSECRETIN.