CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041397
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neural cell expressed, developmentally down-regulated 1, isoform CRA_c 
Protein Synonyms/Alias
 Protein NEDD1 
Gene Name
 NEDD1 
Gene Synonyms/Alias
 hCG_33123 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
246ILYDTSSKKLVKTLVubiquitination[1]
247LYDTSSKKLVKTLVAubiquitination[1]
250TSSKKLVKTLVADTPubiquitination[2]
278AIGSSRGKIYQYDLRubiquitination[1]
378GTVAVQEKAGLPRSIubiquitination[1]
398SKETDSGKNQDFSSFubiquitination[2]
577VASSLSEKIADSIGNubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 667 AA 
Protein Sequence
MHFTGAVMQE NLRFASSGDD IKIWDASSMT LVDKFNPHTS PHGISSICWS SNNNFLVTAS 60
SSGDKIVVSS CKCKPVPLLE LAEGQKQTCV NLNSTSMYLV SGGLNNTVNI WDLKSKRVHR 120
SLKDHKDQVT CVTYNWNDCY IASGSLSGEI ILHSVTTNLS STPFGHGSNQ SVRHLKYSLF 180
KKSLLGSVSD NGIVTLWDVN SQSPYHNFDS VHKAPASGIC FSPVNELLFV TIGLDKRIIL 240
YDTSSKKLVK TLVADTPLTA VDFMPDGATL AIGSSRGKIY QYDLRMLKSP VKTISAHKTS 300
VQCIAFQYST VLTKSSLNKG CSNKPTTVNK RSVNVNAASG GVQNSGIVRE APATSIATVL 360
PQPMTSAMGK GTVAVQEKAG LPRSINTDTL SKETDSGKNQ DFSSFDDTGK SSLGDMFSPI 420
RDDAVVNKGS DESIGKGDGF DFLPQLNSVF PPRKNPVTSS TSVLHSSPLN VFMGSPGKEE 480
NENRDLTAES KKIYMGKQES KDSFKQLAKL VTSGAESGNL NTSPSSNQTR NSEKFEKPEN 540
EIEAQLICEP PINGSSTPNP KIASSVTAGV ASSLSEKIAD SIGNNRQNAP LTSIQIRFIQ 600
NMIQETLDDF REACHRDIVN LQVEMIKQFH MQLNEMHSLL ERYSVNEGLV AEIERLREEN 660
KRLRAHF 667 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0005814; C:centriole; IEA:Compara.
 GO:0005932; C:microtubule basal body; IEA:Compara.
 GO:0000242; C:pericentriolar material; IEA:Compara.
 GO:0000922; C:spindle pole; IEA:Compara. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS