UniProt Accession

 BRMS1_HUMAN; Q9HCU9; Q6IAI2 

Genbank Protein ID

 AF159141; AF281036; CR457173; AK313773; BC009834 

Genbank Nucleotide ID

 AAG00075.1; AAK69131.1; CAG33454.1; BAG36511.1; AAH09834.1 

Protein Name

 Breast cancer metastasis-suppressor 1 

Protein Synonyms/Alias

  

Gene Name

 BRMS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
75	EKQFSELKEKLFRER	ubiquitination	[1]
149	KQHLESEKLLLYDTL	ubiquitination	[1]
184	SSEWWDDKLHARGSS	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. 

Sequence Annotation

  

Keyword

 3D-structure; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0051059; F:NF-kappaB binding; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:2000210; P:positive regulation of anoikis; IMP:UniProtKB.
 GO:0090312; P:positive regulation of protein deacetylation; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013907; Sds3. 

Pfam

 PF08598; Sds3 

SMART

  

PROSITE

  

PRINTS