UniProt Accession

 AL1A2_RAT; Q63639; Q4FZY8 

Genbank Protein ID

 BC098910; U60063 

Genbank Nucleotide ID

 AAH98910.1; AAC52637.1 

Protein Name

 Retinal dehydrogenase 2 

Protein Synonyms/Alias

 RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II) 

Gene Name

 Aldh1a2 

Gene Synonyms/Alias

 Raldh2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
365	EQGPQIDKKQYNKIL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently. 

Sequence Annotation

 NP_BIND 263 268 NAD (By similarity).
 ACT_SITE 286 286 Proton acceptor.
 ACT_SITE 320 320 Nucleophile.
 MOD_RES 119 119 Phosphothreonine (By similarity).
 MOD_RES 122 122 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; NAD; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 518 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; IEA:Compara.
 GO:0016918; F:retinal binding; IDA:RGD.
 GO:0001758; F:retinal dehydrogenase activity; IDA:RGD.
 GO:0042904; P:9-cis-retinoic acid biosynthetic process; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0001568; P:blood vessel development; IEA:Compara.
 GO:0048738; P:cardiac muscle tissue development; IEA:Compara.
 GO:0071300; P:cellular response to retinoic acid; IEA:Compara.
 GO:0009855; P:determination of bilateral symmetry; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; IEA:Compara.
 GO:0048566; P:embryonic digestive tract development; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0060324; P:face development; IEA:Compara.
 GO:0003007; P:heart morphogenesis; IEA:Compara.
 GO:0030902; P:hindbrain development; IEA:Compara.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0007494; P:midgut development; IEP:RGD.
 GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0014032; P:neural crest cell development; IEA:Compara.
 GO:0021915; P:neural tube development; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0031016; P:pancreas development; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEP:RGD.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0009954; P:proximal/distal pattern formation; IEA:Compara.
 GO:0001936; P:regulation of endothelial cell proliferation; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0033189; P:response to vitamin A; IEP:RGD.
 GO:0042574; P:retinal metabolic process; IEA:Compara.
 GO:0002138; P:retinoic acid biosynthetic process; IMP:RGD.
 GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Compara.
 GO:0042572; P:retinol metabolic process; IEA:UniProtKB-UniPathway.
 GO:0035799; P:ureter maturation; IEA:Compara. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS