CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020850
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase 
Protein Synonyms/Alias
  
Gene Name
 Lhpp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
155PVLISLGKGRYYKETubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). 
Sequence Annotation
 REGION 17 19 Substrate binding (By similarity).
 REGION 54 55 Substrate binding (By similarity).
 METAL 17 17 Magnesium (By similarity).
 METAL 19 19 Magnesium; via carbonyl oxygen (By
 METAL 214 214 Magnesium (By similarity).
 BINDING 189 189 Substrate (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 270 AA 
Protein Sequence
MAAWAERLTG VRGVLLDISG VLCDSSASGA TAIAGSVEAV ARLKQSPLKV RFCTNESQKS 60
LRELVGVLQQ LGFDISEEEV TAPAPATCQI LKERGLRPHL LIHEGVRSEF DDIDMSNPNC 120
VVIADAGEAF SYQNMNRAFQ VLMELENPVL ISLGKGRYYK ETSGLMLDVG GYMKALEYAC 180
GIKAEVVGKP SPEFFKSALQ AIGVEAHQAI MIGDDIVGDV GGAQQCGMRA LQVRTGKFRP 240
GDEHHPEVQA DGYVDNLAEA VDLLLKYTDK 270 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0004427; F:inorganic diphosphatase activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
 GO:0008969; F:phosphohistidine phosphatase activity; ISS:UniProtKB.
 GO:0006470; P:protein dephosphorylation; ISS:UniProtKB. 
Interpro
 IPR023214; HAD-like_dom.
 IPR006357; HAD-SF_hydro_IIA.
 IPR006355; HAD-SF_hydro_IIA_hyp2.
 IPR023215; NPhePase-like_dom. 
Pfam
 PF13344; Hydrolase_6 
SMART
  
PROSITE
  
PRINTS