CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TELO2-interacting protein 2 
Protein Synonyms/Alias
  
Gene Name
 TTI2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91QVAKALEKYAAPSKEubiquitination[1, 2]
97EKYAAPSKEEEGGGDubiquitination[1, 2, 3]
112GHSEAAEKAAQVGLLubiquitination[2]
126LFLKLLGKVETAKNSubiquitination[2]
200HGENEDEKGRLSVILubiquitination[2]
211SVILGLLKPDLYKESubiquitination[2]
220DLYKESWKNNPAIKHubiquitination[2]
298LEKTLHWKGDGARPTubiquitination[2]
443RCSQGRVKGLLAKIPubiquitination[2]
448RVKGLLAKIPQSCEDubiquitination[2, 3]
457PQSCEDRKVVNYIRKubiquitination[2]
464KVVNYIRKVQQVSEGubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 477 AA 
Protein Sequence
MELDSALEAP SQEDSNLSEE LSHSAFGQAF SKILHCLARP EARRGNVKDA VLKDLGDLIE 60
ATEFDRLFEG TGARLRGMPE TLGQVAKALE KYAAPSKEEE GGGDGHSEAA EKAAQVGLLF 120
LKLLGKVETA KNSLVGPAWQ TGLHHLAGPV YIFAITHSLE QPWTTPRSRE VAREVLTSLL 180
QVTECGSVAG FLHGENEDEK GRLSVILGLL KPDLYKESWK NNPAIKHVFS WTLQQVTRPW 240
LSQHLERVLP ASLVISDDYQ TENKILGVHC LHHIVLNVAV LLCLLDLFPI LEKTLHWKGD 300
GARPTTHCDE VLRLILTHME PEHRLLLRRT YARNLPAFVN RLGILTVRHL KRLERVIIGY 360
LEVYDGPEEE ARLKILETLK LLMQHTWPRV SCRLVVLLKA LLKLICDVAR DPNLTPESVK 420
SALLQEATDC LILLDRCSQG RVKGLLAKIP QSCEDRKVVN YIRKVQQVSE GAPYNGT 477 
Gene Ontology
  
Interpro
 IPR018870; DUF2454. 
Pfam
 PF10521; DUF2454 
SMART
  
PROSITE
  
PRINTS