| Tag | Content |
|---|
| CPLM ID | CPLM-012786 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase TRIM39 |
Protein Synonyms/Alias | Tripartite motif-containing protein 39 |
Gene Name | TRIM39 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Pan troglodytes (Chimpanzee) |
NCBI Taxa ID | 9598 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 92 | GSMVEIAKQLQAVKR | ubiquitination | [1] | | 452 | PFTPLHIKVKPKRVG | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). |
Sequence Annotation | DOMAIN 319 514 B30.2/SPRY.
ZN_FING 29 70 RING-type.
ZN_FING 102 143 B box-type. |
Keyword | Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Ligase; Metal-binding; Mitochondrion; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 518 AA |
Protein Sequence | MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL 60
ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE 120
DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG 180
ELKRLVESRR QQILREFEEL HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL 240
AHLAAEVEGK CLQSGFEMLK DVKSTLEKNI PRKFGGSLSR ICPRDHKALL GLVKEINRCE 300
KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL VLSEDRKSVK 360
FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL 420
TPLPETGYWR VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI 480
YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE 518 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |