UniProt Accession

 RL6_ECOLI; P0AG55; P02390; Q2M6X0 

Genbank Protein ID

 X01563; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA25720.1; AAA58102.1; AAC76330.1; BAE77986.1 

Protein Name

 50S ribosomal protein L6 

Protein Synonyms/Alias

  

Gene Name

 rplF 

Gene Synonyms/Alias

 b3305; JW3267 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
18	VPAGVDVKINGQVIT	acetylation	[1]
27	NGQVITIKGKNGELT	acetylation	[1]
29	QVITIKGKNGELTRT	acetylation	[1, 2]
44	LNDAVEVKHADNTLT	acetylation	[1, 2, 3]
85	GVTEGFTKKLQLVGV	acetylation	[1]
86	VTEGFTKKLQLVGVG	acetylation	[1, 2]
138	IVLKGADKQVIGQVA	acetylation	[1]
158	YRRPEPYKGKGVRYA	acetylation	[1, 2]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842] 

Functional Description

 This protein binds directly to at least 2 domains of the 23S ribosomal RNA, thus is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. 

Sequence Annotation

 MOD_RES 44 44 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Antibiotic resistance; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0019843; F:rRNA binding; IEA:HAMAP.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR000702; Ribosomal_L6.
 IPR020040; Ribosomal_L6_a/b-dom.
 IPR019906; Ribosomal_L6_bac-type.
 IPR002358; Ribosomal_L6_CS. 

Pfam

 PF00347; Ribosomal_L6 

SMART

  

PROSITE

 PS00525; RIBOSOMAL_L6_1 

PRINTS

 PR00059; RIBOSOMALL6.