CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020990
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pre-mRNA-splicing factor SYF1 
Protein Synonyms/Alias
 XPA-binding protein 2 
Gene Name
 Xab2 
Gene Synonyms/Alias
 Syf1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
454ENYDEALKLLRKATAubiquitination[1]
794QPPRAQSKIFFVRSDacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing (By similarity). 
Sequence Annotation
 REPEAT 15 47 HAT 1.
 REPEAT 48 80 HAT 2.
 REPEAT 90 122 HAT 3.
 REPEAT 124 158 HAT 4.
 REPEAT 160 192 HAT 5.
 REPEAT 198 230 HAT 6.
 REPEAT 235 268 HAT 7.
 REPEAT 270 305 HAT 8.
 REPEAT 369 407 HAT 9.
 REPEAT 498 530 HAT 10.
 REPEAT 532 566 HAT 11.
 REPEAT 571 605 HAT 12.
 REPEAT 643 677 HAT 13.
 REPEAT 679 713 HAT 14.
 MOD_RES 420 420 N6-acetyllysine (By similarity).
 MOD_RES 851 851 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; DNA damage; DNA repair; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Spliceosome; Transcription. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 855 AA 
Protein Sequence
MVVMARVPRS ERPDLVFEEE DLPYEEEIMR NQFSVKCWLR YIEFKQGAPK PRLNQLYERA 60
LKLLPCSYKL WYRYLKARRA QVKHRCVTDP AYEDVNNCHE RAFVFMHKMP RLWLDYCQFL 120
MDQGRVTHTR RTFDRALRAL PITQHSRIWP LYLRFLRSHP LPETAVRGYR RFLKLSPESA 180
EEYIEYLKSS DRLDEAAQRL ATVVNDERFV SKAGKSNYQL WHELCDLISQ NPDKVQSLNV 240
DAIIRGGLTR FTDQLGKLWC SLADYYIRSG HFEKARDVYE EAIRTVMTVR DFTQVFDSYA 300
QFEESMIAAK METASELGRE EEDDVDLELR LARFEQLISR RPLLLNSVLL RQNPHHVHEW 360
HKRVALHQGR PREIINTYTE AVQTVDPFKA TGKPHTLWVA FAKFYEDNGQ LDDARVILEK 420
ATKVNFKQVD DLASVWCQCG ELELRHENYD EALKLLRKAT ALPARRAEYF DGSEPVQNRV 480
YKSLKVWSML ADLEESLGTF QSTKAVYDRI LDLRIATPQI VINYAMFLEE HKYFEESFKA 540
YERGISLFKW PNVSDIWSTY LTKFISRYGG RKLERARDLF EQALDGCPPK YAKTLYLLYA 600
QLEEEWGLAR HAMAVYDRAT RAVEPAQQYD MFNIYIKRAA EIYGVTHTRG IYQKAIEVLS 660
DEHAREMCLR FADMECKLGE IDRARAIYSF CSQICDPRTT GAFWQTWKDF EVRHGNEDTI 720
REMLRIRRSV QATYNTQVNF MASQMLKVSG SATGTVSDLA PGQSGMDDMK LLEQRAEQLA 780
AEAERDQPPR AQSKIFFVRS DASREELAEL AQQANPEEIQ LGEDEDEDEM DLEPNEVRLE 840
QQSVPAAVFG SLKED 855 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0001824; P:blastocyst development; IMP:MGI.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; ISS:UniProtKB.
 GO:0006283; P:transcription-coupled nucleotide-excision repair; ISS:UniProtKB. 
Interpro
 IPR003107; HAT.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF07719; TPR_2 
SMART
 SM00386; HAT 
PROSITE
  
PRINTS