CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039409
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 6-phosphogluconate dehydrogenase, decarboxylating 
Protein Synonyms/Alias
  
Gene Name
 Kif1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
193AFNRTVSKVDDFLAKacetylation[1]
200KVDDFLAKEAKGTKVacetylation[1]
214VIGAKSLKDMVSKLKacetylation[1]
219SLKDMVSKLKKPRRVacetylation[1]
231RRVILLVKAGQAVDDacetylation[1]
309KEAWPHIKTIFQAIAacetylation[1]
443KFQDTDGKELLPKIRacetylation[1]
448DGKELLPKIRDSAGQacetylation[1]
503SRKLKGPKMVQLEGSacetylation[1]
511MVQLEGSKQAFLEDVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; NADP; Oxidoreductase; Pentose shunt; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1089 AA 
Protein Sequence
MDQKTPEANS RASSPCQEFE QFQIIPTVET PYLARAGKNE FLNLVPDIEE VRAGSVVSKK 60
GYLHFKEPLS SNWAKHFVVV RRPYVFIYNS DKDPVERGII NLSTAQVEYS EDQQAMLKTP 120
NTFAVCTKHR GVLLQALNDK DMNDWLYAFN PLLAGTIRAD IALIGLAVMG QNLILNMNDH 180
GFVVCAFNRT VSKVDDFLAK EAKGTKVIGA KSLKDMVSKL KKPRRVILLV KAGQAVDDFI 240
EKLVPLLDTG DIIIDGGNSE YRDTTRRCQD LKAKGILFVG SGVSGGEEGA RYGPSLMPGG 300
NKEAWPHIKT IFQAIAAKVG TGEPCCDWAS SGLPFDECTA GERTLWSQWL ALCCEPLRLK 360
SLSQLVPEVG DEGAGHFVKM VHNGIEYGDM QLICEAYHLM KDVLGMRHEE MAQAFEDWNK 420
TELDSFLIEI TANILKFQDT DGKELLPKIR DSAGQKGTGK WTAISALEYG MPVTLIGEAV 480
FARCLSSLKE ERVQASRKLK GPKMVQLEGS KQAFLEDVRK ALYASKIISY AQGFMLLRQA 540
ATEFGWTLNY GGIALMWRGG CIIRSVFLGK IKDAFERNPE LQNLLLDDFF KSAVDDCQDS 600
WRRVISTGVQ AGIPMPCFTT ALSFYDGYRH EMLPANLIQA QRDYFGAHTY ELLSKPGEFI 660
HTNWTGHGGT LGRGSFEEEE EEEEGKKKKE GKERERERER ERERNKKKKR REGRKKEGEV 720
ERESRRTVAL LPGLSAVMEE VEAEEQQQYS HRQRLKAAVH YTVGCLCQEV ELDKQVHLSK 780
QTIAAISEVT FRQCENFAKD LEMFARHAKR STITTDDVKL LLRRSNSLCV TEDSVGVTED 840
SVSVTEDSVG VTEDSVGVTE DSVTEDSVGV TEDSVTEDSV GVTEDSVSVT EDSVGVTEDS 900
VTEDSVGITE DSVGVTEDSV TEHSVGVTED SVSVTEDSVT EDSVSVTEDS VSVTEDSVSV 960
TEDSVSVTED SVSVTEDSVS VTEDSVSVTE DSVSVTEDSH RLQVSKEDGW LQHKRQAAVS 1020
PQSAAAAAAL GDRSLCPPPG ERSHRPGQCE LSSVRLAVYS DMSWCNSKEA KRVSRLAVRY 1080
VVVTTTLCF 1089 
Gene Ontology
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:EC.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR006114; 6PGDH_C.
 IPR006113; 6PGDH_decarbox.
 IPR006115; 6PGDH_NADP-bd.
 IPR006184; 6PGdom_BS.
 IPR013328; DH_multihelical.
 IPR012284; Fibritin/6PGD_C-extension.
 IPR009072; Histone-fold.
 IPR016040; NAD(P)-bd_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00393; 6PGD
 PF03446; NAD_binding_2
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS00461; 6PGD
 PS50003; PH_DOMAIN 
PRINTS