UniProt Accession

 PARK7_MOUSE; Q99LX0; O88306; Q3THB9; Q3U509 

Genbank Protein ID

 AB015652; AK146368; AK153948; AK168341; AL607084; BC002187 

Genbank Nucleotide ID

 BAA29063.2; BAE27118.1; BAE32271.1; BAE40278.1; CAM19230.1; AAH02187.1 

Protein Name

 Protein DJ-1 

Protein Synonyms/Alias

 Parkinson disease protein 7 homolog 

Gene Name

 Park7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
32	VMRRAGIKVTVAGLA	ubiquitination	[1]
41	TVAGLAGKDPVQCSR	ubiquitination	[1]
130	VTTHPLAKDKMMNGS	acetylation	[2]
132	THPLAKDKMMNGSHY	ubiquitination	[1]
148	YSESRVEKDGLILTS	acetylation	[2]
148	YSESRVEKDGLILTS	ubiquitination	[1]
182	KDMANQVKAPLVLKD	acetylation	[3]
182	KDMANQVKAPLVLKD	succinylation	[3]
182	KDMANQVKAPLVLKD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. 

Sequence Annotation

 ACT_SITE 106 106 By similarity.
 ACT_SITE 126 126 By similarity.
 MOD_RES 67 67 Phosphotyrosine (By similarity).
 MOD_RES 106 106 Cysteine sulfinic acid (-SO2H) (By
 CROSSLNK 130 130 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Autophagy; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Fertilization; Hydrolase; Inflammatory response; Isopeptide bond; Mitochondrion; Nucleus; Oxidation; Phosphoprotein; Protease; Reference proteome; RNA-binding; Stress response; Tumor suppressor; Ubl conjugation; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003729; F:mRNA binding; ISS:UniProtKB.
 GO:0008233; F:peptidase activity; ISS:UniProtKB.
 GO:0004601; F:peroxidase activity; IMP:UniProtKB.
 GO:0051920; F:peroxiredoxin activity; IMP:MGI.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0008283; P:cell proliferation; TAS:MGI.
 GO:0070301; P:cellular response to hydrogen peroxide; IMP:UniProtKB.
 GO:0051583; P:dopamine uptake involved in synaptic transmission; IMP:MGI.
 GO:0042743; P:hydrogen peroxide metabolic process; IMP:MGI.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0051899; P:membrane depolarization; IMP:MGI.
 GO:0060081; P:membrane hyperpolarization; IMP:MGI.
 GO:0007005; P:mitochondrion organization; IMP:UniProtKB.
 GO:0060548; P:negative regulation of cell death; IMP:UniProtKB.
 GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; ISS:UniProtKB.
 GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IMP:UniProtKB.
 GO:0050821; P:protein stabilization; IMP:UniProtKB.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0060765; P:regulation of androgen receptor signaling pathway; IEA:Compara.
 GO:0050727; P:regulation of inflammatory response; IMP:UniProtKB.
 GO:0043523; P:regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0007338; P:single fertilization; IEA:UniProtKB-KW. 

Interpro

 IPR006287; DJ1.
 IPR002818; ThiJ/PfpI. 

Pfam

 PF01965; DJ-1_PfpI 

SMART

  

PROSITE

  

PRINTS