CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004369
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Deoxyguanosinetriphosphate triphosphohydrolase 
Protein Synonyms/Alias
 dGTP triphosphohydrolase; dGTPase 
Gene Name
 dgt 
Gene Synonyms/Alias
 b0160; JW0156 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
23YRSPQGVKTEHEILRacetylation[1]
82QVGRYIAKEILSRLKacetylation[1]
231ETHHYLMKKPGYYLSacetylation[1]
318VVENAWEKSRSNSLSacetylation[1]
343LRVNTLNKLVPYAAQacetylation[1]
388LYKNVAVKHVFSHPDacetylation[1]
461AYVEAVSKLPSDSPEacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. 
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 505 AA 
Protein Sequence
MAQIDFRKKI NWHRRYRSPQ GVKTEHEILR IFESDRGRII NSPAIRRLQQ KTQVFPLERN 60
AAVRTRLTHS MEVQQVGRYI AKEILSRLKE LKLLEAYGLD ELTGPFESIV EMSCLMHDIG 120
NPPFGHFGEA AINDWFRQRL HPEDAESQPL TDDRCSVAAL RLRDGEEPLN ELRRKIRQDL 180
CHFEGNAQGI RLVHTLMRMN LTWAQVGGIL KYTRPAWWRG ETPETHHYLM KKPGYYLSEE 240
AYIARLRKEL NLALYSRFPL TWIMEAADDI SYCVADLEDA VEKRIFTVEQ LYHHLHEAWG 300
QHEKGSLFSL VVENAWEKSR SNSLSRSTED QFFMYLRVNT LNKLVPYAAQ RFIDNLPAIF 360
AGTFNHALLE DASECSDLLK LYKNVAVKHV FSHPDVERLE LQGYRVISGL LEIYRPLLSL 420
SLSDFTELVE KERVKRFPIE SRLFHKLSTR HRLAYVEAVS KLPSDSPEFP LWEYYYRCRL 480
LQDYISGMTD LYAWDEYRRL MAVEQ 505 
Gene Ontology
 GO:0050897; F:cobalt ion binding; IDA:EcoliWiki.
 GO:0008832; F:dGTPase activity; IDA:EcoCyc.
 GO:0003924; F:GTPase activity; IDA:EcoliWiki.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030145; F:manganese ion binding; IDA:EcoliWiki.
 GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
 GO:0003697; F:single-stranded DNA binding; IDA:EcoCyc.
 GO:0006203; P:dGTP catabolic process; IEA:InterPro.
 GO:0015949; P:nucleobase-containing small molecule interconversion; IDA:EcoCyc.
 GO:0043099; P:pyrimidine deoxyribonucleoside salvage; IGI:EcoCyc. 
Interpro
 IPR006261; dGTP_triP_hydro.
 IPR023293; dGTP_triP_hydro_central.
 IPR020779; dGTP_triP_hydro_proteobacteria.
 IPR027432; dGTP_triphosphohydrolase_C_dom.
 IPR003607; HD/PDEase_dom.
 IPR006674; HD_domain. 
Pfam
 PF01966; HD 
SMART
 SM00471; HDc 
PROSITE
  
PRINTS