| Tag | Content |
|---|
| CPLM ID | CPLM-013796 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WW domain-binding protein 11 |
Protein Synonyms/Alias | WBP-11; Splicing factor that interacts with PQBP-1 and PP1 |
Gene Name | Wbp11 |
Gene Synonyms/Alias | Sipp1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 13 | TSSTKSGKFMNPTDQ | acetylation | [1] | | 565 | ATATISAKPQITNPK | acetylation | [1] | | 626 | VPVSVQTKDDVYEAF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity (By similarity). |
Sequence Annotation | REGION 1 45 Required for nuclear import (By
REGION 217 221 Interaction with PP1 (By similarity).
REGION 306 310 Interaction with PP1 (By similarity).
MOTIF 455 466 PGR.
MOD_RES 13 13 N6-acetyllysine (By similarity).
MOD_RES 181 181 Phosphoserine (By similarity).
MOD_RES 237 237 Phosphoserine (By similarity).
MOD_RES 279 279 Phosphoserine (By similarity).
MOD_RES 283 283 Phosphoserine (By similarity).
MOD_RES 353 353 Phosphoserine (By similarity).
MOD_RES 361 361 Phosphoserine (By similarity).
MOD_RES 364 364 Phosphoserine (By similarity). |
Keyword | Acetylation; Coiled coil; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 641 AA |
Protein Sequence | MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP KQIIRDMEKL 60
DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN PDIYKELRKL EVEYEQKRAQ 120
LSQYFDAVKN AQHVEVESIP LPDMPHAPSN ILIQDIPLPG AQPPSILKKT SAYGPPTRAV 180
SILPLLGHGV PRLPPGRKPP GPPPGPPPPQ VLQMYGRKVG FALDLPPRRR DEDMLYSPEL 240
AQRGHDDDMS STSEDDGYPE DMDQDKHDDS TEDSDTDRSD AESDGDEFGH RDDSERDNTE 300
EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE EFSEEEDDDD 360
SEDSEAEKPS QKQHKEDSHA DGSSAASSQQ QAPPQAVPPS QIQAPPMPGP PPLGPPPAPP 420
LRPPGPPTGL PPGPPPGAPP FLRPPGMPGI RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP 480
GPPPRGPPPR LPPPAPPGIP PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPSL 540
IQRPKADDAS AATIEKKATA TISAKPQITN PKAEVTRFVP TALRVRRENK GATAVPQRRS 600
EEDSAVPVAK AAPRSGPSVP VSVQTKDDVY EAFMKEMEGL L 641 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |