UniProt Accession

 UB2L6_HUMAN; O14933; A6NDM6; A8MY53; Q8N5D8; Q9UEZ0 

Genbank Protein ID

 AJ243268; AJ243269; AJ243270; AJ243271; AF061736; AK315755; CR457126; AK226165; AP002893; CH471076; CH471076; BC032491; AF031141 

Genbank Nucleotide ID

 CAB64566.1; CAB64566.1; CAB64566.1; CAB64566.1; AAD17525.1; BAG38109.1; CAG33407.1; EAW73757.1; EAW73759.1; AAH32491.1; AAB86433.1 

Protein Name

 Ubiquitin/ISG15-conjugating enzyme E2 L6 

Protein Synonyms/Alias

 Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6 

Gene Name

 UBE2L6 

Gene Synonyms/Alias

 UBCH8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	MASMRVVKELEDLQK	ubiquitination	[1]
16	KELEDLQKKPPPYLR	ubiquitination	[1]
138	QNPELFRKNAEEFTL	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. 

Sequence Annotation

 ACT_SITE 86 86 Glycyl thioester intermediate (By  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Ligase; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 153 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0042296; F:ISG15 ligase activity; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; TAS:ProtInc.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0032020; P:ISG15-protein conjugation; IEA:Compara.
 GO:0019941; P:modification-dependent protein catabolic process; IEA:Compara.
 GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome. 

Interpro

 IPR000608; UBQ-conjugat_E2.
 IPR023313; UBQ-conjugating_AS.
 IPR016135; UBQ-conjugating_enzyme/RWD. 

Pfam

 PF00179; UQ_con 

SMART

  

PROSITE

 PS00183; UBIQUITIN_CONJUGAT_1
 PS50127; UBIQUITIN_CONJUGAT_2 

PRINTS