UniProt Accession

 STRAP_MOUSE; Q9Z1Z2; Q8BP89; Q8C6F6 

Genbank Protein ID

 AF096285; AK075804; AK077504; AK145971; AK152283 

Genbank Nucleotide ID

 AAC98300.1; BAC35972.1; BAC36834.1; BAE26796.1; BAE31097.1 

Protein Name

 Serine-threonine kinase receptor-associated protein 

Protein Synonyms/Alias

 UNR-interacting protein 

Gene Name

 Strap 

Gene Synonyms/Alias

 Unrip 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
73	TLNKDATKAATAAAD	ubiquitination	[1]
104	LAHKHIVKTVDFTQD	acetylation	[2]
122	LLTGGQDKLLRIYDL	acetylation	[3]
122	LLTGGQDKLLRIYDL	ubiquitination	[1]
131	LRIYDLNKPEAEPKE	ubiquitination	[1]
156	ALWCSDDKQILSADD	acetylation	[2]
249	GEDFKLYKYDYNSGE	acetylation	[2]
262	GEELESYKGHFGPIH	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein (By similarity). 

Sequence Annotation

 REPEAT 12 56 WD 1.
 REPEAT 57 96 WD 2.
 REPEAT 98 137 WD 3.
 REPEAT 141 179 WD 4.
 REPEAT 180 212 WD 5.
 REPEAT 221 262 WD 6.
 REPEAT 263 302 WD 7.
 MOD_RES 335 335 Phosphoserine (By similarity).
 MOD_RES 338 338 Phosphoserine (By similarity).
 MOD_RES 342 342 Phosphotyrosine.  

Keyword

 Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Spliceosome; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 350 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0005102; F:receptor binding; IDA:MGI.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:MGI.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.