| Tag | Content |
|---|
| CPLM ID | CPLM-001585 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger and BTB domain-containing protein 7A |
Protein Synonyms/Alias | Factor binding IST protein 1; FBI-1; Factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor; POK erythroid myeloid ontogenic factor; Pokemon; TTF-I-interacting peptide 21; TIP21; Zinc finger protein 857A |
Gene Name | ZBTB7A |
Gene Synonyms/Alias | FBI1; LRF; ZBTB7; ZNF857A |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 61 | ACSQYFKKLFTSGAV | sumoylation | [1] |
|
Reference | [1] Regulation of pokemon 1 activity by sumoylation. Roh HE, Lee MN, Jeon BN, Choi WI, Kim YJ, Yu MY, Hur MW. Cell Physiol Biochem. 2007;20(1-4):167-80. [ PMID: 17595526] |
Functional Description | Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). |
Sequence Annotation | DOMAIN 34 101 BTB.
ZN_FING 382 404 C2H2-type 1.
ZN_FING 410 432 C2H2-type 2.
ZN_FING 438 460 C2H2-type 3.
ZN_FING 466 490 C2H2-type 4; atypical.
MOD_RES 337 337 Phosphoserine.
MOD_RES 341 341 Phosphoserine.
MOD_RES 495 495 Phosphoserine (By similarity).
MOD_RES 511 511 Phosphoserine.
MOD_RES 525 525 Phosphoserine.
MOD_RES 526 526 Phosphoserine.
MOD_RES 549 549 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; Developmental protein; Differentiation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 584 AA |
Protein Sequence | MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS VLAACSQYFK 60
KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS TANVGDILSA ARLLEIPAVS 120
HVCADLLDRQ ILAADAGADA GQLDLVDQID QRNLLRAKEY LEFFQSNPMN SLPPAAAAAA 180
ASFPWSAFGA SDDDLDATKE AVAAAVAAVA AGDCNGLDFY GPGPPAERPP TGDGDEGDSN 240
PGLWPERDED APTGGLFPPP VAPPAATQNG HYGRGGEEEA ASLSEAAPEP GDSPGFLSGA 300
AEGEDGDGPD VDGLAASTLL QQMMSSVGRA GAAAGDSDEE SRADDKGVMD YYLKYFSGAH 360
DGDVYPAWSQ KVEKKIRAKA FQKCPICEKV IQGAGKLPRH IRTHTGEKPY ECNICKVRFT 420
RQDKLKVHMR KHTGEKPYLC QQCGAAFAHN YDLKNHMRVH TGLRPYQCDS CCKTFVRSDH 480
LHRHLKKDGC NGVPSRRGRK PRVRGGAPDP SPGATATPGA PAQPSSPDAR RNGQEKHFKD 540
EDEDEDVASP DGLGRLNVAG AGGGGDSGGG PGAATDGNFT AGLA 584 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; ISS:UniProtKB. GO:0035035; F:histone acetyltransferase binding; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |