CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010597
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tubulin alpha-3 chain 
Protein Synonyms/Alias
 Mechanosensory abnormality protein 12; MEC-12 
Gene Name
 mec-12 
Gene Synonyms/Alias
 tba-3; C44B11.3 
Created Date
 July 27, 2013 
Organism
 Caenorhabditis elegans 
NCBI Taxa ID
 6239 
Lysine Modification
Position
Peptide
Type
References
40DGQMPSDKSLGGSDDacetylation[1, 2]
Reference
 [1] MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans.
 Fukushige T, Siddiqui ZK, Chou M, Culotti JG, Gogonea CB, Siddiqui SS, Hamelin M.
 J Cell Sci. 1999 Feb;112 ( Pt 3):395-403. [PMID: 9885292]
 [2] MEC-17 is an alpha-tubulin acetyltransferase.
 Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J.
 Nature. 2010 Sep 9;467(7312):218-22. [PMID: 20829795] 
Functional Description
 Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Component of the large-diameter neuronal microtubules which contains 15 protofilaments. 
Sequence Annotation
 NP_BIND 142 148 GTP (Potential).
 MOD_RES 40 40 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; GTP-binding; Microtubule; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MREVISIHIG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK SLGGSDDSFS TFFSETGSGR 60
HVPRAVMVDL EPTVIDEIRT GTYRSLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLTLD 120
RIRRLADNCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKAKLEFS IYPAPQVSTA 180
VVEPYNSILT THTTLEHSDC SFMVDNEAIY DICRRNLDIE RPSYTNLNRL IGQIVSSITA 240
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TFSPVISAEK AYHEQLSVAE ITNMCFEPHN 300
QMVKCDPRHG KYMAVCLLFR GDVVPKDVNA AIATIKTKRS IQFVDWCPTG FKVGINYQPP 360
TVVPGGDLAK VPRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 420
AREDLAALEK DYEEVGVDSM EDNGEEGDEY 450 
Gene Ontology
 GO:0030424; C:axon; IDA:WormBase.
 GO:0005874; C:microtubule; IDA:WormBase.
 GO:0043025; C:neuronal cell body; IDA:WormBase.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0005200; F:structural constituent of cytoskeleton; ISS:WormBase.
 GO:0007638; P:mechanosensory behavior; IMP:WormBase.
 GO:0007017; P:microtubule-based process; IMP:WormBase.
 GO:0051258; P:protein polymerization; IEA:InterPro.
 GO:0001966; P:thigmotaxis; IMP:WormBase. 
Interpro
 IPR002452; Alpha_tubulin.
 IPR008280; Tub_FtsZ_C.
 IPR000217; Tubulin.
 IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
 IPR023123; Tubulin_C.
 IPR017975; Tubulin_CS.
 IPR003008; Tubulin_FtsZ_GTPase. 
Pfam
 PF00091; Tubulin
 PF03953; Tubulin_C 
SMART
 SM00864; Tubulin
 SM00865; Tubulin_C 
PROSITE
 PS00227; TUBULIN 
PRINTS
 PR01162; ALPHATUBULIN.
 PR01161; TUBULIN.